{"id":"W2988721710","doi":"10.3389/fbioe.2019.00294","title":"Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model","year":2019,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fundação para a Ciência e a Tecnologia; Universidade do Minho","keywords":"Mesenchymal stem cell; Neuroprotection; Cell biology; Progenitor cell; Transplantation; Parkinson's disease; Dopaminergic; Neuroscience; Biology; Dopamine; Stem cell; Medicine; Pathology; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327921,0.000503249,0.0005256785,0.0004394111,0.0001190546,0.0002047629,0.0001139148,0.0002655856,0.0009873497],"category_scores_gemma":[0.00007899359,0.00009076292,0.0003865307,0.0002002499,0.0002359288,0.0001919257,0.0001497357,0.000878689,0.0002075349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009233076,"about_ca_system_score_gemma":0.0002063446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005037162,"about_ca_topic_score_gemma":0.0009506865,"domain_scores_codex":[0.9999005,0.00001114629,0.00001070167,0.00001795271,0.00004159893,0.00001815942],"domain_scores_gemma":[0.9999348,0.000006009864,0.00001674434,0.000006067024,0.00001109231,0.00002535397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005601329,0.0002298717,0.0001988044,0.0001296368,0.00001754593,0.00005978256,0.00003160889,0.00006104079,0.993244,0.00006693356,0.00006065292,0.005340034],"study_design_scores_gemma":[0.00006102569,0.002649929,0.005896348,0.00002691546,0.00008175271,0.0001242604,0.00005208109,0.000440814,0.9882087,0.00008275119,0.002368989,0.000006505552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916026,0.003928845,0.002501073,0.0001706965,0.0001028072,0.00004344459,0.0004625906,0.000130904,0.001056844],"genre_scores_gemma":[0.9901325,0.003725513,0.002708529,0.00008950287,0.00004772904,0.00007739662,0.0007888942,0.00001945783,0.002410596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009873497,"threshold_uncertainty_score":0.003302991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004990210761595196,"score_gpt":0.1922266289201374,"score_spread":0.1872364181585423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}