{"id":"W2988725855","doi":"10.3390/molecules24224016","title":"Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)","year":2019,"lang":"en","type":"article","venue":"Molecules","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of North Carolina at Chapel Hill; Biocenter Finland; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novartis Pharma; China Scholarship Council; Pfizer","keywords":"Kinome; Kinase; In vivo; Cytochrome P450; Microsome; Chemistry; Biochemistry; IC50; Biology; In vitro; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004265347,0.0004863548,0.0002392524,0.0001914556,0.0001855114,0.0003091897,0.0004223255,0.0004897848,0.001397898],"category_scores_gemma":[0.0002109719,0.0001677879,0.0002461038,0.0001358519,0.0003070649,0.0003294246,0.0002221821,0.001095827,0.0005294986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005241275,"about_ca_system_score_gemma":0.0002809739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003540596,"about_ca_topic_score_gemma":0.0007649099,"domain_scores_codex":[0.9998473,0.00004745282,0.000006612074,0.00004163994,0.00002604757,0.00003098587],"domain_scores_gemma":[0.9998877,0.0000282846,0.00003100007,0.00001703919,0.00001614729,0.00001989393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000061111,0.00003206986,0.00004282227,0.00004886344,0.000003971496,0.00003083016,0.00001578783,0.0001129968,0.9977189,0.0004727463,0.00007970711,0.001380232],"study_design_scores_gemma":[0.00001900215,0.0003966049,0.0003161764,0.000003582335,0.000008974197,0.0001581228,0.00001048546,0.0003530828,0.9937404,0.00008963006,0.004898744,0.00000518485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8976964,0.00615587,0.08487568,0.001155457,0.0001912592,0.000341465,0.0009086229,0.0004618717,0.008213378],"genre_scores_gemma":[0.9598708,0.003285401,0.02977469,0.0003102495,0.00003714122,0.0001558761,0.0007088699,0.00006096958,0.005796036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397898,"threshold_uncertainty_score":0.004676461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410392799244444,"score_gpt":0.2563265782918489,"score_spread":0.2422226502994045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}