{"id":"W2988829006","doi":"10.1093/neuros/nyz442","title":"A Phase II Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases: Clinical Trial Protocol","year":2019,"lang":"en","type":"article","venue":"Neurosurgery","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Western Hospital","funders":"","keywords":"Radiosurgery; Medicine; Toxicity; Clinical trial; Radiation therapy; Stereotactic radiation therapy; Cohort; Clinical endpoint; Randomized controlled trial; Surgery; Prospective cohort study; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00331768,0.0003797332,0.001703249,0.0002713221,0.0001203096,0.00002902268,0.0001258724,0.0001172076,0.0003726939],"category_scores_gemma":[0.00158006,0.0002894154,0.0009240467,0.0003314335,0.00004531655,0.0001443044,0.0001108443,0.0003045464,0.00002672531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003524444,"about_ca_system_score_gemma":0.0003176186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001349728,"about_ca_topic_score_gemma":0.000003216545,"domain_scores_codex":[0.9954848,0.0007620548,0.001800953,0.0007973163,0.0005787086,0.0005761792],"domain_scores_gemma":[0.9947377,0.003032364,0.0007070532,0.001060169,0.0001569458,0.000305777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5228313,0.2915693,0.06526355,0.00129686,0.002675661,0.001559704,0.0005147917,0.00001010497,0.001307065,0.0002411486,0.0585942,0.05413633],"study_design_scores_gemma":[0.6840419,0.1404836,0.003616752,0.0001586902,0.001062713,0.0001152491,0.0003074776,0.0004810987,0.000432261,0.0000301747,0.1688596,0.0004105782],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8475756,0.00001789814,0.00007092529,0.0004094507,0.001247406,0.1503524,0.0001976213,0.00006644748,0.00006226686],"genre_scores_gemma":[0.9368524,0.000002730454,0.0002695328,0.001383663,0.0004458824,0.06005516,0.00008280446,0.00009023328,0.0008176023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1612106,"threshold_uncertainty_score":0.9999558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09509320432431834,"score_gpt":0.4320241569832265,"score_spread":0.3369309526589082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}