{"id":"W2988958689","doi":"10.1126/science.aay0793","title":"Brain cell type–specific enhancer–promoter interactome maps and disease <b>-</b> risk association","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":793,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Veterans Affairs San Diego Healthcare System; University of California, San Diego; Universitair Medisch Centrum Groningen; Centre Hospitalier Universitaire de Québec; National Center for Advancing Translational Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Rijksuniversiteit Groningen; Ludwig Institute for Cancer Research; Université Laval; U.S. Department of Veterans Affairs; Cancer Research Institute; JPB Foundation; National Institute on Aging; Alzheimer's Association; Cure Alzheimer's Fund","keywords":"Enhancer; Interactome; Biology; Microglia; Phenotype; Promoter; Gene; Cell type; Genetics; Genetic association; Computational biology; Cell; Gene expression; Single-nucleotide polymorphism; Genotype; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227466,0.0002153071,0.0003159085,0.001482991,0.0002866564,0.0005486248,0.0001902085,0.0004466571,0.006190132],"category_scores_gemma":[0.0006340856,0.0001927723,0.0004255684,0.001357249,0.0002045414,0.0002471893,0.000421057,0.0004646464,0.0007741211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002429888,"about_ca_system_score_gemma":0.0002050206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001870502,"about_ca_topic_score_gemma":0.003390384,"domain_scores_codex":[0.9997566,0.00003217065,0.00001119302,0.0001170869,0.00004542274,0.00003744006],"domain_scores_gemma":[0.9994866,0.0002194974,0.0001365242,0.0000416244,0.00005037139,0.00006537063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002517803,0.0001678802,0.4638197,0.0006098337,0.001714827,0.002569276,0.0006796735,0.002404962,0.420253,0.006795818,0.01594759,0.08251961],"study_design_scores_gemma":[0.00005013939,0.00006841573,0.9608398,0.0000505258,0.0004126044,0.002201327,0.0002005134,0.004665496,0.01251118,0.005260656,0.01370938,0.00002990074],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680228,0.003830309,0.006148677,0.001465805,0.00007584769,0.00001933071,0.01450784,0.0002633063,0.005666085],"genre_scores_gemma":[0.9856818,0.001189593,0.002302614,0.0002291545,0.00006108236,0.00002736173,0.008106832,0.00005393214,0.002347595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006190132,"threshold_uncertainty_score":0.02070802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003089231221610902,"score_gpt":0.2102791624103814,"score_spread":0.2071899311887705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}