{"id":"W2988958689","doi":"10.1126/science.aay0793","title":"Brain cell type–specific enhancer–promoter interactome maps and disease <b>-</b> risk association","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":793,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Veterans Affairs San Diego Healthcare System; University of California, San Diego; Universitair Medisch Centrum Groningen; Centre Hospitalier Universitaire de Québec; National Center for Advancing Translational Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Rijksuniversiteit Groningen; Ludwig Institute for Cancer Research; Université Laval; U.S. Department of Veterans Affairs; Cancer Research Institute; JPB Foundation; National Institute on Aging; Alzheimer's Association; Cure Alzheimer's Fund","keywords":"Enhancer; Interactome; Biology; Microglia; Phenotype; Promoter; Gene; Cell type; Genetics; Genetic association; Computational biology; Cell; Gene expression; Single-nucleotide polymorphism; Genotype; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004401798,0.00006962149,0.00005872878,0.00002777351,0.00007519353,0.00007478951,0.0001620213,0.00004657625,0.00003897109],"category_scores_gemma":[0.00006682605,0.00006098129,0.00002212437,0.0001114221,0.00006555534,0.00001248931,0.0001248715,0.00007517522,0.0001264519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002951091,"about_ca_system_score_gemma":0.00008078365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000202704,"about_ca_topic_score_gemma":0.000001989795,"domain_scores_codex":[0.9993246,0.00001540535,0.0001031082,0.0002286876,0.0001309718,0.0001971788],"domain_scores_gemma":[0.9994859,0.00001221565,0.00009157573,0.0002267474,0.00006105457,0.0001225542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006395978,0.00003786789,0.02922859,0.00002898649,0.000008974438,7.324221e-7,0.0002608328,0.0000536044,0.9427718,0.0001197319,0.01365997,0.01376493],"study_design_scores_gemma":[0.001660461,0.0007068163,0.1087708,0.00006654647,0.00002884567,0.00000575322,0.0002549361,0.005623004,0.1681837,0.004217106,0.7094736,0.001008513],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958399,0.0005816819,0.0004220955,0.0002338742,0.000424501,0.0001210753,0.00001584278,0.000005236098,0.002355829],"genre_scores_gemma":[0.9956986,0.0002621875,0.0003277069,0.0003387314,0.00008737022,0.000001837287,0.00001810168,0.0000051048,0.003260318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7745882,"threshold_uncertainty_score":0.2486745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003089231221610902,"score_gpt":0.2102791624103814,"score_spread":0.2071899311887705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}