{"id":"W2989048325","doi":"10.3390/pharmaceutics11110587","title":"IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening","year":2019,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal","keywords":"IVIVC; In vivo; In vitro; Permeability (electromagnetism); Blood–brain barrier; Drug; Chemistry; Pharmacology; Cell; Membrane permeability; Cell culture; Cell biology; Biology; Membrane; Biochemistry; Biopharmaceutics Classification System; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001366521,0.0009498626,0.001128867,0.00137042,0.0002594151,0.0008157775,0.0004788675,0.0006330693,0.001149542],"category_scores_gemma":[0.001015784,0.0002463352,0.0005084751,0.0009950409,0.0002864845,0.0004017647,0.0004127547,0.001384647,0.0004317912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005147752,"about_ca_system_score_gemma":0.0005067202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003100034,"about_ca_topic_score_gemma":0.003386771,"domain_scores_codex":[0.9987986,0.0003294057,0.0001352728,0.0002311864,0.0003746628,0.0001308129],"domain_scores_gemma":[0.9984554,0.0003010353,0.0002467338,0.0002403553,0.0005733529,0.0001830884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004131109,0.0003076835,0.00206143,0.0001430403,0.00005478713,0.0001104313,0.00007800185,0.0005956469,0.9893818,0.0002016668,0.0002077526,0.006444584],"study_design_scores_gemma":[0.00001970197,0.003218881,0.009709387,0.00001637453,0.0001851676,0.0003871681,0.00007120209,0.004752446,0.9786604,0.0001101265,0.002844868,0.00002430662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8945738,0.008434203,0.0863877,0.0002659297,0.0002300875,0.0005397172,0.004150979,0.0009170192,0.00450054],"genre_scores_gemma":[0.930128,0.006321917,0.04921145,0.000178804,0.00005475067,0.0008209817,0.005315362,0.0001278197,0.007840762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003100034,"threshold_uncertainty_score":0.007226944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04883760064864582,"score_gpt":0.3723233244144868,"score_spread":0.323485723765841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}