{"id":"W2989217594","doi":"10.1097/ccm.0000000000004087","title":"Critical Care Management of Toxicities Associated With Targeted Agents and Immunotherapies for Cancer","year":2019,"lang":"en","type":"review","venue":"Critical Care Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Toronto General Hospital","funders":"National Cancer Institute","keywords":"Medicine; Adverse effect; Cytokine release syndrome; Immunotherapy; Cancer; Cancer immunotherapy; Immunology; Internal medicine; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002113352,0.00057555,0.002673642,0.0002193462,0.0001057378,0.00001982667,0.0001750468,0.0003772491,0.0003739133],"category_scores_gemma":[0.0003239837,0.0003715455,0.0003612052,0.0003005429,0.001345842,0.0000547716,0.00004342863,0.0003312163,0.000001255407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003988804,"about_ca_system_score_gemma":0.0002865776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008306426,"about_ca_topic_score_gemma":0.00002111414,"domain_scores_codex":[0.9974149,0.0001096952,0.0007960513,0.0005814472,0.0005884372,0.0005094321],"domain_scores_gemma":[0.9974971,0.0008993951,0.000147683,0.000450159,0.0008349264,0.000170767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007071668,0.00007147544,0.00004714656,0.2577646,0.001701139,0.00006494123,0.001777811,3.280512e-8,0.000006916158,0.0007820959,0.0007687173,0.736308],"study_design_scores_gemma":[0.006277066,0.004360685,0.0005689672,0.189859,0.01680813,0.00004938682,0.02401537,0.000002702572,0.00002677646,0.00003819113,0.7572881,0.0007056394],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001136576,0.9942783,0.0000700064,0.0007741565,0.000699011,0.002075553,0.000677485,0.00005289757,0.001258966],"genre_scores_gemma":[0.01026666,0.9869708,0.0002497052,0.0005416574,0.0002569438,0.0005257794,0.0006895646,0.0001044582,0.0003943926],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7565194,"threshold_uncertainty_score":0.9998736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0665410540857086,"score_gpt":0.4045305031470224,"score_spread":0.3379894490613138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}