{"id":"W2989217594","doi":"10.1097/ccm.0000000000004087","title":"Critical Care Management of Toxicities Associated With Targeted Agents and Immunotherapies for Cancer","year":2019,"lang":"en","type":"review","venue":"Critical Care Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Toronto General Hospital","funders":"National Cancer Institute","keywords":"Medicine; Adverse effect; Cytokine release syndrome; Immunotherapy; Cancer; Cancer immunotherapy; Immunology; Internal medicine; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002853443,0.0007634338,0.002016432,0.005703,0.0006248201,0.001393136,0.0008670627,0.001002169,0.005627433],"category_scores_gemma":[0.01059788,0.0001790454,0.00175857,0.00512491,0.0005620217,0.001508738,0.0006936693,0.0007968997,0.0005345433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002032454,"about_ca_system_score_gemma":0.004817611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001932489,"about_ca_topic_score_gemma":0.004208522,"domain_scores_codex":[0.99638,0.001241421,0.001492345,0.0001525369,0.0006125731,0.0001211844],"domain_scores_gemma":[0.9892757,0.004731334,0.004444024,0.0001268174,0.001238926,0.0001831419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001270749,0.0001513319,0.01004844,0.448599,0.002143396,0.001841776,0.0005189725,0.0008368218,0.001213929,0.002858657,0.04084595,0.489671],"study_design_scores_gemma":[0.001199574,0.001404914,0.0521735,0.5498793,0.005320129,0.01304116,0.001744152,0.0008148995,0.001945755,0.005426168,0.3668685,0.0001820207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007155523,0.9719881,0.001684435,0.002970569,0.0005063147,0.002401702,0.003415752,0.00004434693,0.009833178],"genre_scores_gemma":[0.08100642,0.8885696,0.01327854,0.005427796,0.001538963,0.004424688,0.004082281,0.00002809329,0.001643506],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005703,"threshold_uncertainty_score":0.01882559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0665410540857086,"score_gpt":0.4045305031470224,"score_spread":0.3379894490613138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}