{"id":"W2989265170","doi":"10.1182/blood-2019-127562","title":"Ibrutinib in Combination with Venetoclax Decreases Mitochondrial Bioenergetics through the Impaired BTK, AKT and AMPK/SIRT/PGC-1α Signaling Pathway in CLL","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"Ibrutinib; Bruton's tyrosine kinase; AMPK; Protein kinase B; Chronic lymphocytic leukemia; Cancer research; Venetoclax; Signal transduction; Biology; AMP-activated protein kinase; Cell biology; Phosphorylation; Tyrosine kinase; Protein kinase A; Leukemia; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189965,0.000202793,0.0003581975,0.0001301462,0.00005328726,0.00005112801,0.0001729057,0.0001481477,0.00004673474],"category_scores_gemma":[0.0002437878,0.0001370323,0.00004896912,0.0004643677,0.0001598137,0.0001157868,0.0001035532,0.0002951205,0.00001984873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001576516,"about_ca_system_score_gemma":0.003345749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002123797,"about_ca_topic_score_gemma":0.0005622566,"domain_scores_codex":[0.9981076,0.0001523927,0.000352812,0.0003851503,0.0005439502,0.0004581189],"domain_scores_gemma":[0.9988472,0.0004361123,0.00009291227,0.0004340911,0.00008341136,0.0001062246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02173521,0.02233777,0.4018979,0.004276253,0.001662141,0.005416791,0.04083414,0.006414243,0.4681609,0.01444339,0.001884443,0.01093684],"study_design_scores_gemma":[0.4394092,0.007292529,0.02285023,0.003225732,0.0003871481,0.001285623,0.004760509,0.02190372,0.4900771,0.002736055,0.00477744,0.001294653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997003,0.000781079,0.00002289965,0.0002972555,0.000106339,0.001141341,0.000005971101,0.00003573952,0.0006063941],"genre_scores_gemma":[0.9985357,0.00006324199,0.0007725079,0.0001590485,0.0001477146,0.00006268974,0.00004025276,0.00003851892,0.0001803568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.417674,"threshold_uncertainty_score":0.5935215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549933302437428,"score_gpt":0.2600591317277591,"score_spread":0.2445597987033848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}