{"id":"W2989339993","doi":"10.1038/s41594-019-0321-z","title":"Multiple direct interactions of TBP with the MYC oncoprotein","year":2019,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor; University of Toronto; Structural Genomics Consortium; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"TATA-Box Binding Protein; TATA-binding protein; Transcription factor; Transcription preinitiation complex; TAF2; General transcription factor; Transcription factor II D; Transcription (linguistics); Transcription factor II A; Cell biology; Biology; Chemistry; Gene; Promoter; DNA-binding protein; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057047,0.0001708498,0.0001948467,0.00004941436,0.00006902879,0.00001238069,0.0003370238,0.0002606629,0.00004856714],"category_scores_gemma":[0.0001172365,0.00009661495,0.0001133117,0.0001416723,0.0001566236,0.000004033514,0.0001297012,0.0004588882,0.000006747048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000136586,"about_ca_system_score_gemma":0.00006457261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009169894,"about_ca_topic_score_gemma":0.0001491398,"domain_scores_codex":[0.9989498,0.0001378818,0.0001420476,0.0003506166,0.0001249447,0.0002947686],"domain_scores_gemma":[0.9991965,0.0000313571,0.00009900207,0.0004721052,0.0001435024,0.00005757722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002352638,0.00000598175,0.004573525,0.00001085084,0.0001100474,0.000003433754,0.00001314131,0.00006268575,0.9926029,0.0005452196,0.0002336572,0.001603239],"study_design_scores_gemma":[0.0007060289,0.0006812972,0.005794425,0.00001539651,0.00001511868,0.00004976408,0.00006556119,0.0001715185,0.9760646,0.0001022915,0.01615009,0.0001839113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959196,0.00108253,0.0004062071,0.0007181902,0.0001574966,0.0003929222,0.00003052601,0.000009787525,0.001282749],"genre_scores_gemma":[0.9976749,0.00001293529,0.0006519466,0.0004341757,0.00008523151,0.0000176718,0.0001365752,0.00001936987,0.0009672174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01653836,"threshold_uncertainty_score":0.3939843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002876537650844975,"score_gpt":0.2856496646077352,"score_spread":0.2827731269568902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}