{"id":"W2989339993","doi":"10.1038/s41594-019-0321-z","title":"Multiple direct interactions of TBP with the MYC oncoprotein","year":2019,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor; University of Toronto; Structural Genomics Consortium; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"TATA-Box Binding Protein; TATA-binding protein; Transcription factor; Transcription preinitiation complex; TAF2; General transcription factor; Transcription factor II D; Transcription (linguistics); Transcription factor II A; Cell biology; Biology; Chemistry; Gene; Promoter; DNA-binding protein; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864261,0.0003192657,0.0002965033,0.0003322965,0.0006220841,0.0009713318,0.0003150128,0.0004762216,0.002448274],"category_scores_gemma":[0.0006697263,0.0003415208,0.0003914941,0.0003243477,0.0002305595,0.0005601163,0.0008953926,0.0009404751,0.0009631541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005676913,"about_ca_system_score_gemma":0.0001855108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000490703,"about_ca_topic_score_gemma":0.0009905145,"domain_scores_codex":[0.9994872,0.00005697762,0.00002751734,0.0001161076,0.0001961751,0.0001161218],"domain_scores_gemma":[0.9994988,0.0002054297,0.00005964666,0.00007410747,0.00004918257,0.0001127431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001589229,0.00001590258,0.0009406261,0.00004142251,0.00002218981,0.0003122136,0.00002545348,0.00009046309,0.9950619,0.0004838159,0.0001493272,0.002697725],"study_design_scores_gemma":[0.00001186205,0.00005704813,0.008089587,0.000007205423,0.00002293953,0.001236081,0.0000592908,0.001268194,0.9861547,0.0002854831,0.00279888,0.000008694707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884824,0.003706181,0.003142486,0.0001760176,0.00003643692,0.000009505971,0.0001851644,0.00005773865,0.004204137],"genre_scores_gemma":[0.9961239,0.0004796657,0.001057786,0.00004160131,0.00001244394,0.00000902165,0.000252978,0.00002636506,0.00199621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002448274,"threshold_uncertainty_score":0.008190274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002876537650844975,"score_gpt":0.2856496646077352,"score_spread":0.2827731269568902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}