{"id":"W2989359658","doi":"10.1182/blood-2019-124091","title":"Efficacy and Safety in 15 Hemophilia B Patients Treated with the AAV Gene Therapy Vector Fidanacogene Elaparvovec and Followed for at Least 1 Year","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Dosing; Tolerability; Factor IX; Genetic enhancement; Adverse effect; Internal medicine; Pharmacokinetics; Gastroenterology; Pharmacology; Immunology; Urology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005260582,0.0004487032,0.0006778868,0.0002278062,0.0003852368,0.0004019521,0.0001232999,0.0003739419,0.0005981862],"category_scores_gemma":[0.0006930002,0.0001560704,0.0005029965,0.0001921441,0.0004292954,0.0002226699,0.0002287548,0.0004961395,0.000140614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003916641,"about_ca_system_score_gemma":0.0002557347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007123055,"about_ca_topic_score_gemma":0.0004504414,"domain_scores_codex":[0.9997649,0.00005801576,0.00002747421,0.00005450836,0.00004145291,0.00005363361],"domain_scores_gemma":[0.9995515,0.0001126809,0.0001282193,0.00002357982,0.00003186135,0.0001522608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04545323,0.01677002,0.7124494,0.0002442223,0.0007016911,0.004165794,0.002090871,0.00437026,0.07334347,0.0001886497,0.0007690322,0.1394534],"study_design_scores_gemma":[0.004061396,0.3217297,0.6519597,0.00003874347,0.0005172241,0.005306855,0.0003261928,0.002223855,0.01159536,0.0001024634,0.002094541,0.00004385824],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995197,0.0001816209,0.000071276,0.00001033504,0.000001772087,0.00002387217,0.00003659657,0.000004367541,0.0001504676],"genre_scores_gemma":[0.9993635,0.0001207711,0.0001432699,0.00004104305,0.000006856039,0.00002855076,0.0001657893,0.00000135252,0.0001288749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007123055,"threshold_uncertainty_score":0.002841711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00762021038364892,"score_gpt":0.2341076885924007,"score_spread":0.2264874782087518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}