{"id":"W2989462885","doi":"10.1210/clinem/dgz102","title":"Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits","year":2019,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Association Vaincre la Mucoviscidose; Sorbonne Université; Institut National de la Santé et de la Recherche Médicale; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Ontario Genomics Institute; Gilead Sciences; Cystic Fibrosis Canada; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; National Institutes of Health; Ontario Genomics; Genome Canada; Cystic Fibrosis Foundation","keywords":"TCF7L2; Cystic fibrosis-related diabetes; Type 2 diabetes; Genome-wide association study; Diabetes mellitus; Medicine; Internal medicine; Population; Context (archaeology); Insulin; Insulin resistance; Genetic association; Endocrinology; Biology; Single-nucleotide polymorphism; Genetics; Impaired glucose tolerance; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009965872,0.0005642548,0.0005612526,0.001217549,0.0005318768,0.0006284057,0.0004011763,0.0008201873,0.003034651],"category_scores_gemma":[0.004254373,0.0001933709,0.0008516309,0.00180018,0.0006396116,0.0002378223,0.0007296778,0.0005468693,0.0001721919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608486,"about_ca_system_score_gemma":0.0002905345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002074401,"about_ca_topic_score_gemma":0.002782786,"domain_scores_codex":[0.9986094,0.0003924214,0.0001493841,0.0004780116,0.0002428358,0.0001278846],"domain_scores_gemma":[0.9958575,0.001816142,0.001587893,0.0003307627,0.0001526298,0.0002549806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006800961,0.00004960816,0.9790807,0.00008312202,0.0006826989,0.001159412,0.00008545884,0.0002253283,0.008529128,0.000162047,0.0001538752,0.009108636],"study_design_scores_gemma":[0.00002993466,0.0001112089,0.9954282,0.0000238207,0.0002974079,0.002714802,0.00004364699,0.0002804847,0.0005160348,0.0001838433,0.0003639625,0.000006647134],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963981,0.001229879,0.001063617,0.0001258468,0.00001469182,0.00001875389,0.0004837435,0.00002332179,0.00064198],"genre_scores_gemma":[0.9982929,0.0003379644,0.0007527184,0.00005554258,0.00002986894,0.0000114108,0.0003986825,0.000007058215,0.000113879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003034651,"threshold_uncertainty_score":0.01015192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820099298907534,"score_gpt":0.3235043412354142,"score_spread":0.3053033482463388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}