{"id":"W2989462885","doi":"10.1210/clinem/dgz102","title":"Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits","year":2019,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Association Vaincre la Mucoviscidose; Sorbonne Université; Institut National de la Santé et de la Recherche Médicale; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Ontario Genomics Institute; Gilead Sciences; Cystic Fibrosis Canada; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; National Institutes of Health; Ontario Genomics; Genome Canada; Cystic Fibrosis Foundation","keywords":"TCF7L2; Cystic fibrosis-related diabetes; Type 2 diabetes; Genome-wide association study; Diabetes mellitus; Medicine; Internal medicine; Population; Context (archaeology); Insulin; Insulin resistance; Genetic association; Endocrinology; Biology; Single-nucleotide polymorphism; Genetics; Impaired glucose tolerance; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001065379,0.0002696196,0.001715937,0.0002343694,0.00005862127,0.0000115338,0.0003275404,0.000194196,0.0001737189],"category_scores_gemma":[0.003738081,0.0001510678,0.0002575199,0.0003118122,0.00133379,0.0001441098,0.0001111048,0.00132749,0.00002798082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001740738,"about_ca_system_score_gemma":0.0002715892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006493635,"about_ca_topic_score_gemma":0.000001280598,"domain_scores_codex":[0.9960158,0.0007561133,0.001718548,0.0002837654,0.0005967659,0.0006290309],"domain_scores_gemma":[0.9934609,0.003860174,0.001100469,0.0004166555,0.0008451306,0.0003166679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01597255,0.001225602,0.5081527,0.0007124733,0.008993837,0.0004605562,0.00165161,0.00279333,0.3835103,0.001517641,0.001130035,0.07387939],"study_design_scores_gemma":[0.007896696,0.004573946,0.9755709,0.0004031177,0.001562743,0.0005770588,0.0003878264,0.0008852942,0.004461265,0.002190579,0.001304747,0.0001857933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746736,0.02300769,0.00001103333,0.001064486,0.0004984929,0.0004473926,0.000008322548,0.00001642747,0.0002725012],"genre_scores_gemma":[0.9940204,0.002963039,0.002200943,0.000262826,0.0001459321,0.000002731201,0.000002280944,0.00003882645,0.0003630251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4674183,"threshold_uncertainty_score":0.6160367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820099298907534,"score_gpt":0.3235043412354142,"score_spread":0.3053033482463388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}