{"id":"W2989463773","doi":"10.1126/scitranslmed.aaw0475","title":"Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers","year":2019,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs; Multiple Sclerosis Society of Canada","keywords":"Central nervous system; Cell adhesion molecule; Adhesion; Cell adhesion; Cell biology; Lymphocyte; Cell migration; Neural cell adhesion molecule; Polymorphonuclear leukocyte; Leukocyte Trafficking; Immunology; Biology; Cell; Chemistry; Neuroscience; Immune system; In vitro; Chemokine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006700369,0.0001832736,0.0001802338,0.0004112653,0.0001847419,0.0003482477,0.0001003708,0.0002180459,0.001291828],"category_scores_gemma":[0.0001630071,0.00008731962,0.0001126842,0.0001273,0.0001462083,0.0001373601,0.0001555393,0.0003281069,0.0002657185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372866,"about_ca_system_score_gemma":0.00007940844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006067675,"about_ca_topic_score_gemma":0.0005824646,"domain_scores_codex":[0.999911,0.00002592744,0.000006195618,0.00001719002,0.00001347257,0.00002623706],"domain_scores_gemma":[0.999934,0.000008774951,0.00002370028,0.000002870285,0.00001210097,0.00001853573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008793534,0.00009345105,0.02861949,0.00008040901,0.00008082201,0.0005841234,0.0001428892,0.00008433899,0.9541289,0.0002570937,0.0003251167,0.01472398],"study_design_scores_gemma":[0.0002121287,0.000913173,0.7282572,0.00006410019,0.0002671432,0.004302259,0.0008939683,0.00321017,0.2552817,0.000935213,0.005631138,0.00003174536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997883,0.001225507,0.0002810845,0.00006220038,0.00001019757,0.000003154082,0.00004106759,0.00001335515,0.0004803499],"genre_scores_gemma":[0.9990688,0.0002418522,0.0001567515,0.00002630141,0.000007957429,0.000004650593,0.00004279952,0.000002071921,0.000448811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001291828,"threshold_uncertainty_score":0.004321635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631193974805868,"score_gpt":0.2574545644550214,"score_spread":0.2411426247069627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}