{"id":"W2989468714","doi":"10.1182/blood-2019-122260","title":"The Frequency and Effect of Baseline Cross-Reacting and De Novo Inhibitors to Recombinant Porcine FVIII in Patients with Congenital and Acquired Hemophilia a","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Medicine; Antibody; Recombinant factor VIIa; Recombinant DNA; Isoantibodies; Autoantibody; Immunology; Coagulation; Nijmegen breakage syndrome; Internal medicine; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002489945,0.0003032468,0.0003416116,0.0007243493,0.0003496332,0.000607697,0.0002435192,0.0006766978,0.001871034],"category_scores_gemma":[0.00171245,0.000153438,0.0003337006,0.0005303773,0.0003146383,0.0004695661,0.0002943832,0.0005745877,0.0002877303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859189,"about_ca_system_score_gemma":0.0001922046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094476,"about_ca_topic_score_gemma":0.0008532985,"domain_scores_codex":[0.9995803,0.00008132072,0.00004968756,0.0001060324,0.00007922962,0.0001034213],"domain_scores_gemma":[0.99878,0.0003579624,0.0004667311,0.0000471854,0.00007690419,0.0002712734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003477165,0.00009073153,0.9911806,0.00002325998,0.00004048303,0.003307404,0.0001237728,0.00003719423,0.0005333287,0.00003487592,0.0001311776,0.004149475],"study_design_scores_gemma":[0.00001137616,0.0005424356,0.9788754,0.00001013916,0.00004723916,0.01943248,0.0002368434,0.0001293423,0.0001761801,0.00003894138,0.0004906887,0.000008897282],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981376,0.0008427582,0.00004033424,0.00003149684,0.000007035171,0.000005132542,0.00009661869,0.000003889684,0.0008351442],"genre_scores_gemma":[0.9995695,0.0001614834,0.00002262488,0.00001926559,0.0000165915,0.000002735193,0.00009279996,0.000001321077,0.0001137076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001871034,"threshold_uncertainty_score":0.006259203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00570151503086418,"score_gpt":0.2569814686705513,"score_spread":0.2512799536396871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}