{"id":"W2989507932","doi":"10.1182/blood-2019-127421","title":"NFKBIZ3′ UTR Mutations Confer Selective Growth Advantage and Activate Genes with Therapeutic Implications in Diffuse Large B-Cell Lymphoma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; Simon Fraser University","funders":"","keywords":"Diffuse large B-cell lymphoma; Biology; Untranslated region; Mutation; Gene; Three prime untranslated region; Cancer research; Signal transduction; B cell; Genetics; Lymphoma; Messenger RNA; Molecular biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026899,0.000175598,0.000164871,0.0001279534,0.00008822751,0.0001773801,0.00009226141,0.0002369828,0.001582987],"category_scores_gemma":[0.0001190909,0.00005960527,0.0001305681,0.000111,0.0001519532,0.00008382064,0.0001218761,0.0002537184,0.0002817266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936152,"about_ca_system_score_gemma":0.0001348237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003176008,"about_ca_topic_score_gemma":0.0004289512,"domain_scores_codex":[0.9999386,0.000007501948,0.000005316975,0.00001456403,0.00001597616,0.00001799753],"domain_scores_gemma":[0.9999489,0.00001140694,0.00001436755,0.000004836337,0.0000039148,0.00001657315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003481723,0.00006153831,0.003154392,0.0000451228,0.00001027939,0.0006408044,0.00001514083,0.0002347044,0.9870929,0.0002632792,0.0001442551,0.007989393],"study_design_scores_gemma":[0.0002466353,0.002594482,0.06789742,0.000026044,0.0001537185,0.0241778,0.0001025761,0.003479728,0.8806072,0.0007430084,0.01995206,0.00001933461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950908,0.001752436,0.0007306917,0.00009903325,0.00001376882,0.0000132296,0.0001821601,0.00007517981,0.002042718],"genre_scores_gemma":[0.9985292,0.0002840592,0.0004487573,0.00003636061,0.000004161454,0.000008737722,0.0001861375,0.000006708754,0.0004957218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001582987,"threshold_uncertainty_score":0.005295575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007060586903819591,"score_gpt":0.2375397344838326,"score_spread":0.230479147580013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}