{"id":"W2989513644","doi":"10.1093/neuonc/noz175.050","title":"ACTR-06. CLINICAL TRIAL OF VAL-083 IN NEWLY DIAGNOSED MGMT-UNMETHYLATED GBM: HALF-WAY REPORT","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"","keywords":"Temozolomide; Tolerability; Medicine; Radiation therapy; O-6-methylguanine-DNA methyltransferase; Oncology; Internal medicine; Methyltransferase; Guanine; Stage (stratigraphy); Phases of clinical research; Clinical trial; Nuclear medicine; Cancer research; Biology; DNA; Gene; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002204724,0.001137086,0.001418267,0.0004199909,0.0003815768,0.001002317,0.001022687,0.001742547,0.004744781],"category_scores_gemma":[0.0007733023,0.0004139885,0.001320938,0.0003226988,0.0007497919,0.000886015,0.0003805611,0.003624992,0.001871447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004941275,"about_ca_system_score_gemma":0.001009972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006085812,"about_ca_topic_score_gemma":0.001243191,"domain_scores_codex":[0.9994448,0.0003088952,0.00002787357,0.00005356349,0.00005590194,0.0001090116],"domain_scores_gemma":[0.9991444,0.000141311,0.0001113055,0.00008949082,0.00004982962,0.0004636698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7123053,0.05174854,0.006138801,0.0009205049,0.00152502,0.0005296897,0.0003206202,0.002533354,0.03669978,0.0009250282,0.01552109,0.1708323],"study_design_scores_gemma":[0.4189501,0.5509228,0.0138104,0.00006695638,0.0003426328,0.0004886465,0.0000474509,0.001851443,0.006263396,0.0003191293,0.006890665,0.00004644683],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803628,0.004765526,0.001036873,0.001248177,0.000366366,0.002272361,0.003031085,0.0003358343,0.006580933],"genre_scores_gemma":[0.9751153,0.002527116,0.001792944,0.002655232,0.0003876807,0.002382489,0.004635186,0.0000644014,0.01043969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004744781,"threshold_uncertainty_score":0.01587284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05515892660588789,"score_gpt":0.3857798892029587,"score_spread":0.3306209625970708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}