{"id":"W2989534655","doi":"10.1101/832345","title":"Conversion of Diffusely Abnormal White Matter to Focal Lesions is Linked to Progression in Secondary Progressive Multiple Sclerosis","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; McGill University; Montreal Neurological Institute and Hospital","funders":"International Progressive MS Alliance","keywords":"Expanded Disability Status Scale; Multiple sclerosis; Voxel; White matter; Nuclear medicine; Medicine; Abnormality; Intensity (physics); Internal medicine; Magnetic resonance imaging; Radiology; Physics; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004992751,0.0002877791,0.000330478,0.0009863963,0.0002272337,0.0005125256,0.0001939212,0.0002827144,0.001354322],"category_scores_gemma":[0.00196692,0.0001781804,0.0002186117,0.0004246854,0.0002723586,0.0002711166,0.0003809214,0.000360082,0.000227859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001636248,"about_ca_system_score_gemma":0.0001506836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002315785,"about_ca_topic_score_gemma":0.003879408,"domain_scores_codex":[0.9997745,0.00005140609,0.00002461777,0.00007442464,0.00005588492,0.00001914371],"domain_scores_gemma":[0.9989166,0.0001904244,0.000559981,0.00007031641,0.0001366362,0.0001260017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008117001,0.00009053588,0.9758748,0.00004733038,0.0001231818,0.000315462,0.0001573219,0.0002999972,0.009517419,0.00003949957,0.0001839537,0.01253888],"study_design_scores_gemma":[0.000007087547,0.0001125473,0.998497,0.00000361152,0.00001457423,0.0005335798,0.00004121865,0.0003950695,0.0003009847,0.0000451625,0.00004670404,0.000002471989],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994617,0.00007048613,0.0001655703,0.00001356498,0.000001572714,0.000005380756,0.00007384024,0.00001195772,0.0001960437],"genre_scores_gemma":[0.9995161,0.00002572513,0.0001743099,0.000004581289,0.000004161755,0.000003338596,0.0001362394,0.000002314992,0.0001332004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002315785,"threshold_uncertainty_score":0.004604578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0376398765954661,"score_gpt":0.279204974358763,"score_spread":0.2415650977632968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}