{"id":"W2989608208","doi":"10.1038/s41531-019-0099-z","title":"Freezing of Gait can persist after an acute levodopa challenge in Parkinson’s disease","year":2019,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Parkinsonfonden; U.S. Department of Health and Human Services; National Institutes of Health; Emory University; School of Medicine, Emory University; National Parkinson Foundation","keywords":"Levodopa; Parkinson's disease; Dopaminergic; Dosing; Gait; Medicine; Morning; Psychology; Internal medicine; Disease; Physical therapy; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001213812,0.0004057016,0.0004653741,0.0004292306,0.000269844,0.0004377066,0.0001932309,0.0002385742,0.0004855343],"category_scores_gemma":[0.002542896,0.0001735858,0.0005201334,0.0002966286,0.0003729524,0.0002880457,0.0004356285,0.00028507,0.00006182664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000326065,"about_ca_system_score_gemma":0.0001986682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154198,"about_ca_topic_score_gemma":0.003556409,"domain_scores_codex":[0.9993976,0.0002701494,0.00008611065,0.00006842325,0.0001022038,0.00007538022],"domain_scores_gemma":[0.9982277,0.000717698,0.0007335483,0.00007278747,0.00008896641,0.0001593186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00176488,0.000190036,0.9831834,0.00006184322,0.0001593795,0.0004298206,0.0001245549,0.0002591727,0.002509361,0.0000226587,0.00006647933,0.01122849],"study_design_scores_gemma":[0.00001756711,0.0009920143,0.9967303,0.00001702108,0.00007808152,0.001007411,0.00009627409,0.0004844753,0.0004311002,0.00004551841,0.00009304201,0.00000718427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993462,0.0002461151,0.00008256513,0.000007521008,0.000003101916,0.000008183222,0.00003822099,0.000001871961,0.0002662131],"genre_scores_gemma":[0.9997838,0.00004907719,0.00005374174,0.00001009623,0.000003692335,0.000003602897,0.00007126131,3.718859e-7,0.00002429261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154198,"threshold_uncertainty_score":0.006419361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812699859624453,"score_gpt":0.2635035820440754,"score_spread":0.2453765834478309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}