{"id":"W2989632039","doi":"10.1016/j.molmet.2019.11.004","title":"The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1","year":2019,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Ontario Research Foundation; Medical Research Council; Wellcome; Banting Research Foundation; Joslin Diabetes Center; Wellcome Trust","keywords":"Biology; Circadian rhythm; Circadian clock; Cell biology; Secretion; Endocrinology; Internal medicine; Suprachiasmatic nucleus; CLOCK; Gene knockdown; Zeitgeber; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087917,0.0003120703,0.0002636558,0.0002801121,0.0002215988,0.0002901589,0.0002757057,0.0002293105,0.001508575],"category_scores_gemma":[0.0001591976,0.0001491735,0.0002481624,0.0001706007,0.0002996755,0.0002538505,0.0003888657,0.000382254,0.0003338595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004226211,"about_ca_system_score_gemma":0.000310432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008719225,"about_ca_topic_score_gemma":0.001588861,"domain_scores_codex":[0.999791,0.00001469637,0.00001314525,0.0000620538,0.00006343382,0.00005574952],"domain_scores_gemma":[0.999761,0.00001169676,0.000125771,0.00001448858,0.00002331217,0.00006371549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001817494,0.000006340948,0.0006211653,0.00002873023,0.000003310999,0.00003532898,0.00001038378,0.00003380396,0.9976404,0.00007414002,0.00003856309,0.001326097],"study_design_scores_gemma":[0.00004172911,0.000219491,0.0623466,0.0000203222,0.00004217544,0.0003448074,0.000110799,0.001620023,0.9304568,0.0001266876,0.004658679,0.00001196926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916597,0.001526325,0.004619635,0.0001435894,0.0000419877,0.00002317528,0.0009631474,0.0001778305,0.0008445879],"genre_scores_gemma":[0.9925141,0.0006465932,0.003697842,0.0000851488,0.00001453095,0.00003636014,0.0009249417,0.00004620705,0.002034334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508575,"threshold_uncertainty_score":0.005046666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532868947852833,"score_gpt":0.232082594221205,"score_spread":0.2167539047426766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}