{"id":"W2989632039","doi":"10.1016/j.molmet.2019.11.004","title":"The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1","year":2019,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Ontario Research Foundation; Medical Research Council; Wellcome; Banting Research Foundation; Joslin Diabetes Center; Wellcome Trust","keywords":"Biology; Circadian rhythm; Circadian clock; Cell biology; Secretion; Endocrinology; Internal medicine; Suprachiasmatic nucleus; CLOCK; Gene knockdown; Zeitgeber; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005387309,0.0003360254,0.0004100391,0.0001045146,0.0004283278,0.00009643234,0.0005221354,0.0001696852,0.00003185479],"category_scores_gemma":[0.0003939419,0.0002285632,0.000223824,0.0004153987,0.0002502583,0.0001840748,0.0001446628,0.0003118781,0.00002875741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002541402,"about_ca_system_score_gemma":0.0001570818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001698979,"about_ca_topic_score_gemma":0.00000669731,"domain_scores_codex":[0.9975594,0.0002502984,0.0004251391,0.0006833067,0.0005032377,0.0005786127],"domain_scores_gemma":[0.9981748,0.0001784875,0.0003930593,0.0008764742,0.0001856057,0.0001916074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007761074,0.00003041211,0.0004625054,0.0001165073,0.00003302411,0.00001924758,0.0004912445,0.0001186242,0.9206835,0.07653981,0.0003499459,0.001077547],"study_design_scores_gemma":[0.0009476519,0.00005143556,0.01637007,0.00006810235,0.00007325754,0.00006110411,0.0002923845,0.001365884,0.8664835,0.001367393,0.1125834,0.0003358125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753905,0.01946358,0.0002656839,0.0008936294,0.0006216155,0.002559625,0.0001565206,0.00005603165,0.0005928275],"genre_scores_gemma":[0.9959471,0.0002610927,0.0001587468,0.0009648603,0.0001521199,0.0002680857,0.00002267682,0.00006919228,0.00215612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1122335,"threshold_uncertainty_score":0.9320536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532868947852833,"score_gpt":0.232082594221205,"score_spread":0.2167539047426766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}