{"id":"W2989645149","doi":"10.1126/sciadv.aax4520","title":"In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Institutes of Health; Ministry of Science, ICT and Future Planning; National Institute of Diabetes and Digestive and Kidney Diseases; Ministry of Trade, Industry and Energy","keywords":"Islet; In vivo; Spheroid; Microfluidics; Perfusion; Pancreatic islets; Cell biology; Pathology; Chemistry; Biomedical engineering; In vitro; Biology; Materials science; Nanotechnology; Medicine; Internal medicine; Insulin; Endocrinology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000303213,0.00009375237,0.0002551928,0.0001399524,0.00004915785,0.00001123066,0.0001289304,0.00003374346,0.0007417277],"category_scores_gemma":[0.0002018954,0.00006759669,0.00003931819,0.0007901149,0.0002918823,0.0004760906,0.00003458484,0.00008483668,0.00006808943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005541194,"about_ca_system_score_gemma":0.0001297063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002647828,"about_ca_topic_score_gemma":0.000001081799,"domain_scores_codex":[0.9989308,0.00001452557,0.0001979846,0.0002669386,0.0003488018,0.0002409523],"domain_scores_gemma":[0.999501,0.00004594979,0.00007359089,0.0002222193,0.0000869198,0.00007034076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003000832,0.00003590586,0.1016894,0.00006621793,0.000001502937,0.000001873166,0.0005120421,0.000007825203,0.8960332,0.00006331398,0.0003385649,0.001220154],"study_design_scores_gemma":[0.0008476216,0.0002706764,0.00785779,0.0003695262,0.00001535039,0.00001235246,0.00202667,0.0001174429,0.9751186,0.0002327151,0.01303161,0.00009961995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756172,0.005464917,0.00002365777,0.0001273837,0.0003227598,0.0001946607,0.000001841377,0.00001806209,0.01822949],"genre_scores_gemma":[0.9942017,0.0004954269,0.001204612,0.0004529978,0.00004065604,0.000004480285,0.000001000855,0.000005253587,0.003593897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09383157,"threshold_uncertainty_score":0.8121397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007751584766629007,"score_gpt":0.2690725793904478,"score_spread":0.2613209946238187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}