{"id":"W2989645149","doi":"10.1126/sciadv.aax4520","title":"In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Institutes of Health; Ministry of Science, ICT and Future Planning; National Institute of Diabetes and Digestive and Kidney Diseases; Ministry of Trade, Industry and Energy","keywords":"Islet; In vivo; Spheroid; Microfluidics; Perfusion; Pancreatic islets; Cell biology; Pathology; Chemistry; Biomedical engineering; In vitro; Biology; Materials science; Nanotechnology; Medicine; Internal medicine; Insulin; Endocrinology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059434,0.0003934148,0.0003278152,0.0001360545,0.0001599494,0.0003862766,0.0002839259,0.0003526796,0.0005767948],"category_scores_gemma":[0.0001339793,0.0001674829,0.0003821498,0.0001157272,0.0001954888,0.0002475197,0.0002133846,0.0005195069,0.0002265549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003097804,"about_ca_system_score_gemma":0.0003449319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005949354,"about_ca_topic_score_gemma":0.0008820783,"domain_scores_codex":[0.9998418,0.00001318847,0.00001508876,0.00006520684,0.00003261429,0.00003192564],"domain_scores_gemma":[0.9998541,0.00003509764,0.00003979679,0.00002814972,0.00001588501,0.0000269684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002226848,0.00002160538,0.0001430821,0.00003572277,0.000004085101,0.00005522282,0.00002257343,0.0005768085,0.9980041,0.000124329,0.00008125036,0.0009089889],"study_design_scores_gemma":[0.00001073574,0.000146328,0.001579186,0.000008129538,0.00001756114,0.0001319575,0.00001697295,0.005831667,0.9895151,0.00006250286,0.002670479,0.000009484574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8864545,0.001478948,0.1059071,0.0001954468,0.0002807595,0.0002482663,0.001433058,0.0006077307,0.00339428],"genre_scores_gemma":[0.948152,0.001189898,0.04757148,0.0001109533,0.00004725103,0.0002970094,0.0009079382,0.00007384355,0.001649616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005949354,"threshold_uncertainty_score":0.002247632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007751584766629007,"score_gpt":0.2690725793904478,"score_spread":0.2613209946238187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}