{"id":"W2989714853","doi":"10.3389/fmicb.2019.02665","title":"A Novel Single Domain Antibody Targeting FliC Flagellin of Salmonella enterica for Effective Inhibition of Host Cell Invasion","year":2019,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; Mitacs; Ontario Centres of Excellence","keywords":"Salmonella enterica; Salmonella; Single-domain antibody; Flagellin; Microbiology; Biology; Antibody; Serotype; Pathogen; Virulence factor; Virulence; Bacteria; Gene; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126226,0.0003240649,0.0002150117,0.0001789215,0.0001087002,0.00015666,0.0002260709,0.000338054,0.0005963817],"category_scores_gemma":[0.00007861574,0.00009835811,0.000216355,0.0001277197,0.0001288085,0.0001202527,0.0001705767,0.0004182328,0.0002120212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044116,"about_ca_system_score_gemma":0.0002098659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004828072,"about_ca_topic_score_gemma":0.0008810297,"domain_scores_codex":[0.999909,0.00001257653,0.00000532646,0.00001612748,0.00003009713,0.00002680522],"domain_scores_gemma":[0.9999595,0.000005152396,0.000006659262,0.000002842274,0.00001185934,0.00001402071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002556486,0.000027819,0.00009414772,0.00003269705,0.000002881805,0.00002143148,0.000004244239,0.00006369144,0.9974242,0.00004387894,0.00003923733,0.002220231],"study_design_scores_gemma":[0.00002180489,0.001004934,0.002089915,0.000007567341,0.00001837981,0.0004120064,0.00001360905,0.00163828,0.9916306,0.00002693854,0.003130441,0.000005685487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817266,0.0025795,0.01325994,0.0001521299,0.0000398436,0.00006349821,0.0001571614,0.0001077009,0.001913711],"genre_scores_gemma":[0.9805965,0.001219168,0.01486154,0.0001729874,0.00001228705,0.00004181269,0.0004322548,0.00001068709,0.002652813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005963817,"threshold_uncertainty_score":0.001995087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004438126204230707,"score_gpt":0.2099221949366028,"score_spread":0.2054840687323721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}