{"id":"W2989741907","doi":"10.1016/j.biopha.2019.109657","title":"The effect of genetic variations on ribavirin pharmacokinetics and treatment response in HCV-4 Egyptian patients receiving sofosbuvir/daclatasvir and ribavirin","year":2019,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculté de pharmacie, Université de Montréal","keywords":"Ribavirin; Sofosbuvir; Daclatasvir; Medicine; Internal medicine; Pharmacokinetics; Single-nucleotide polymorphism; Gastroenterology; Pharmacology; Genotype; Virology; Hepatitis C virus; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118926,0.0003258216,0.0005363047,0.0004752535,0.0001087455,0.00002567767,0.0001410893,0.00009429371,0.0001604943],"category_scores_gemma":[0.0001574373,0.0002075246,0.00006368025,0.0005019769,0.0002724747,0.00006370391,0.00004782998,0.0002752611,0.00002923165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273537,"about_ca_system_score_gemma":0.00009619899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002030709,"about_ca_topic_score_gemma":0.00001995761,"domain_scores_codex":[0.9972132,0.0007431271,0.0005560932,0.0004556692,0.0005741826,0.0004577136],"domain_scores_gemma":[0.997632,0.00147292,0.0001465229,0.0004106104,0.00007473699,0.0002632655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008554892,0.0002394952,0.4493795,0.0000683621,0.0001467209,0.00002486192,0.0004803615,0.000006266964,0.1410215,0.000003987365,0.0003468679,0.3997271],"study_design_scores_gemma":[0.02930706,0.01434228,0.8650883,0.0002645837,0.0001202019,0.000007935746,0.00002025662,0.00250966,0.02865423,0.000007035931,0.05946073,0.0002176873],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936979,0.001630243,0.00001735207,0.001705576,0.0002216475,0.002249426,0.0000539014,0.00003008268,0.0003938474],"genre_scores_gemma":[0.9900949,0.008677129,0.0001159453,0.0003642976,0.0001228918,0.0001153282,0.00002652303,0.00005686106,0.0004261318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4157088,"threshold_uncertainty_score":0.8462608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014062992452801,"score_gpt":0.344198032872567,"score_spread":0.330135040419766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}