{"id":"W2989858130","doi":"10.3389/fphar.2019.01372","title":"The Clinical Implications of Nocebo Effects for Biosimilar Therapy","year":2019,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Pfizer","keywords":"Nocebo Effect; Biosimilar; Nocebo; Medicine; Intensive care medicine; Psychosocial; Adverse effect; Disease; Psychological intervention; Rheumatoid arthritis; Alternative medicine; Pharmacology; Psychiatry; Immunology; Placebo; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001710409,0.0003744127,0.002390202,0.000193244,0.0001308737,0.000007508841,0.0009193934,0.00131747,0.00005636259],"category_scores_gemma":[0.0002260895,0.0002224346,0.001009787,0.0003157463,0.0008469536,0.00002085759,0.0001231463,0.0008692231,0.00002349478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006633477,"about_ca_system_score_gemma":0.0003123859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001390548,"about_ca_topic_score_gemma":9.245861e-7,"domain_scores_codex":[0.9958059,0.001839997,0.001228341,0.0005489705,0.00002570136,0.0005511034],"domain_scores_gemma":[0.9936361,0.005161873,0.0006160865,0.0004664345,0.00008597121,0.00003347652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001199228,0.0001500612,0.0001039618,0.001313791,0.001092487,4.983067e-7,0.000004241298,4.000126e-8,0.00007136459,0.0002268802,0.2455453,0.7513715],"study_design_scores_gemma":[0.001644808,0.0003930512,0.00004253339,0.0003057413,0.001227691,0.00000752339,0.000004421969,0.000002487938,0.0003686221,0.0006892723,0.9950867,0.000227152],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002660277,0.9805037,0.001481738,0.0008214021,0.01370082,0.003088866,0.0001843186,0.0000194688,0.0001970166],"genre_scores_gemma":[0.000005993765,0.9948836,0.002533607,0.0006742989,0.0001574575,0.000616829,0.00006598947,0.00004102735,0.001021182],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7511443,"threshold_uncertainty_score":0.999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1281461086588577,"score_gpt":0.4769020353471043,"score_spread":0.3487559266882466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}