{"id":"W2989867137","doi":"10.1021/acschembio.9b00654","title":"Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Division of Molecular and Cellular Biosciences; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; Purdue University; Purdue University Center for Cancer Research; V Foundation for Cancer Research; Canadian Cancer Society Research Institute; Indiana Clinical and Translational Sciences Institute; National Cancer Institute; Prostate Cancer Foundation","keywords":"Chromodomain; Chromatin; Biology; Polycomb-group proteins; Gene; Histone H3; DNA; Lysine; Genetics; Cell biology; Computational biology; Gene expression; Amino acid; Repressor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212778,0.0006719442,0.0004248708,0.0004113772,0.0001306317,0.0004499873,0.0004211222,0.0003838747,0.001770191],"category_scores_gemma":[0.0001990049,0.0002605648,0.0002301262,0.0004241663,0.0001938877,0.0002557208,0.0002690761,0.0005436731,0.0008636934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000511686,"about_ca_system_score_gemma":0.000299286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005732034,"about_ca_topic_score_gemma":0.001163112,"domain_scores_codex":[0.999818,0.00002418364,0.00001293699,0.00004427586,0.00006054678,0.00004003039],"domain_scores_gemma":[0.9999267,0.00001356478,0.00001682406,0.000005215396,0.00001596266,0.00002172655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001250583,0.0001459836,0.0001121403,0.00007855994,0.0000155528,0.0000786814,0.00001864219,0.001418941,0.9910114,0.0002748405,0.0001537528,0.006566346],"study_design_scores_gemma":[0.00006992471,0.0007897067,0.0002938515,0.000007281466,0.00002361928,0.0001419219,0.00002019902,0.002600186,0.9917629,0.00005654246,0.004223699,0.00001019527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489979,0.00258456,0.03604525,0.0002816009,0.00007963874,0.0005654136,0.001638228,0.0006813906,0.009125988],"genre_scores_gemma":[0.9587032,0.002521869,0.02620127,0.0002668662,0.00001972314,0.0003618723,0.002163692,0.0001038509,0.009657667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770191,"threshold_uncertainty_score":0.0059219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069941926602433,"score_gpt":0.2370689868810519,"score_spread":0.2263695676150276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}