{"id":"W2989867168","doi":"10.1101/860395","title":"Antibody responses to immunization require sensory neurons","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Nociceptor; TRPV1; Antigen; Transient receptor potential channel; Neuroscience; Immunization; Immunology; Antibody; Sensory system; Optogenetics; Biology; Medicine; Nociception; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005090472,0.0006551635,0.0005985491,0.0005949485,0.0003509442,0.0003461227,0.001020927,0.000587592,0.0001087929],"category_scores_gemma":[0.001701509,0.0006704392,0.0001999203,0.0009125653,0.0001503592,0.0003031219,0.001116699,0.0009321366,0.0009891675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011633,"about_ca_system_score_gemma":0.0005542554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002557328,"about_ca_topic_score_gemma":3.227366e-7,"domain_scores_codex":[0.9958215,0.0006069179,0.0006028114,0.001591841,0.0006207227,0.0007561942],"domain_scores_gemma":[0.9970714,0.0002473461,0.0004097045,0.001573606,0.0003472731,0.0003506349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007835853,0.00009812247,0.0006609298,0.0001794708,0.00001393263,0.00005524451,0.0000295227,0.0008532773,0.9972667,0.0003986186,0.0003647676,0.000001089591],"study_design_scores_gemma":[0.000274122,0.0001031394,0.008680874,0.0002877717,0.00003252018,4.959878e-8,0.00000475933,0.0007818088,0.9700133,0.00000137736,0.01893554,0.0008846995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872038,0.0001668184,0.002947075,0.0008033264,0.006432517,0.001252737,0.0004520132,0.0006960202,0.00004570473],"genre_scores_gemma":[0.9965751,0.0004175923,0.0006170376,0.001194769,0.0006349421,0.0000710402,7.022766e-7,0.0002216094,0.0002672708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02725333,"threshold_uncertainty_score":0.9997887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03232643228961208,"score_gpt":0.2734366529981105,"score_spread":0.2411102207084985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}