{"id":"W2989899656","doi":"10.1182/blood-2019-129557","title":"Sorafenib in Combination with Standard Chemotherapy for Children with High Allelic Ratio FLT3/ITD+ AML Improves Event-Free Survival and Reduces Relapse Risk: A Report from the Children's Oncology Group Protocol AAML1031","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Sorafenib; Medicine; Internal medicine; Oncology; Cohort; Fms-Like Tyrosine Kinase 3; Induction chemotherapy; Chemotherapy; Chemotherapy regimen; Interim analysis; Clinical trial; Biology; Hepatocellular carcinoma; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001170231,0.0003193422,0.0006317453,0.000116055,0.0001468819,0.00006941499,0.0003280627,0.0002159948,0.0000374939],"category_scores_gemma":[0.0002635992,0.0001909405,0.00006339543,0.0002791809,0.0002195683,0.0001861268,0.0001068994,0.0006003819,0.000003102271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575123,"about_ca_system_score_gemma":0.0008072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002064554,"about_ca_topic_score_gemma":0.0008843348,"domain_scores_codex":[0.99747,0.0002433359,0.0004844171,0.0007239009,0.0006382279,0.0004401004],"domain_scores_gemma":[0.9979915,0.0003098261,0.0004335774,0.0009158682,0.0002224897,0.0001267504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01955132,0.002397921,0.9475489,0.00008729036,0.001867354,0.0001108308,0.001722128,0.000008568286,0.01352012,0.000469247,0.002111251,0.01060503],"study_design_scores_gemma":[0.09709148,0.009384005,0.8753475,0.000156799,0.0002784929,0.0003584607,0.0003010149,0.0000595528,0.01535366,0.0005406582,0.0008063214,0.000322071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9184593,0.00004613752,0.000249719,0.003243664,0.00003472965,0.07766199,0.0001146585,0.0000642719,0.0001255122],"genre_scores_gemma":[0.9607086,0.00004886668,0.006068239,0.0001814019,0.0003114372,0.0316558,0.0005651799,0.0001082788,0.0003522473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07754016,"threshold_uncertainty_score":0.7786326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007366758900743348,"score_gpt":0.2755143311586557,"score_spread":0.2681475722579124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}