{"id":"W2989899656","doi":"10.1182/blood-2019-129557","title":"Sorafenib in Combination with Standard Chemotherapy for Children with High Allelic Ratio FLT3/ITD+ AML Improves Event-Free Survival and Reduces Relapse Risk: A Report from the Children's Oncology Group Protocol AAML1031","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Sorafenib; Medicine; Internal medicine; Oncology; Cohort; Fms-Like Tyrosine Kinase 3; Induction chemotherapy; Chemotherapy; Chemotherapy regimen; Interim analysis; Clinical trial; Biology; Hepatocellular carcinoma; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004813988,0.0009699862,0.00144042,0.000582373,0.0007062081,0.001026747,0.002017727,0.002063888,0.01241771],"category_scores_gemma":[0.004684592,0.0004732641,0.001881569,0.0007621076,0.000421516,0.0005506366,0.0007214758,0.002973053,0.0024361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002721358,"about_ca_system_score_gemma":0.00804566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002322963,"about_ca_topic_score_gemma":0.00649017,"domain_scores_codex":[0.9977081,0.001266939,0.000241178,0.0001679047,0.0003933882,0.0002223816],"domain_scores_gemma":[0.9976563,0.0004726599,0.000737346,0.0001712512,0.0003805826,0.000581741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3064009,0.01236512,0.006709557,0.0104949,0.001698117,0.0006972259,0.0003438438,0.002352922,0.01367231,0.003899171,0.2113806,0.4299854],"study_design_scores_gemma":[0.5750585,0.06355384,0.02842864,0.003881162,0.00134425,0.001337134,0.0001042556,0.001586817,0.007912353,0.002492606,0.3142035,0.00009695891],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.2898445,0.03902794,0.009128237,0.02423606,0.003934323,0.4642681,0.08024551,0.001325815,0.08798948],"genre_scores_gemma":[0.3298081,0.02732224,0.03688961,0.01770771,0.002046677,0.5275688,0.03367346,0.0002749034,0.02470848],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01241771,"threshold_uncertainty_score":0.04154134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007366758900743348,"score_gpt":0.2755143311586557,"score_spread":0.2681475722579124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}