{"id":"W2989904783","doi":"10.1093/neuonc/noz219.1199","title":"LTBK-08. TOCA 511 & TOCA FC VERSUS STANDARD OF CARE IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; University of Alberta; Montreal Neurological Institute and Hospital; University Health Network; CancerCare Manitoba; Sunnybrook Hospital; Ottawa Regional Cancer Foundation; Princess Margaret Cancer Centre","funders":"","keywords":"Temozolomide; Medicine; Clinical endpoint; Internal medicine; Interim analysis; Oncology; Adverse effect; Bevacizumab; Progression-free survival; Glioma; Lomustine; Gastroenterology; Surgery; Randomized controlled trial; Chemotherapy; Cyclophosphamide; Cancer research; Vincristine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009255295,0.0005911805,0.001641867,0.000308274,0.0002109719,0.0006240761,0.000498935,0.0006892525,0.003549705],"category_scores_gemma":[0.0008844631,0.0002157971,0.001263783,0.0003973718,0.0005166543,0.0005509416,0.0002254669,0.001408178,0.0004831062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001359908,"about_ca_system_score_gemma":0.001151133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001598905,"about_ca_topic_score_gemma":0.00482639,"domain_scores_codex":[0.9995213,0.000215792,0.00003017119,0.00008086513,0.00004052806,0.0001114424],"domain_scores_gemma":[0.9995455,0.0001040757,0.0001022083,0.00003230643,0.0000217867,0.0001940797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8458542,0.009422196,0.004146953,0.0007364043,0.001360098,0.0001563015,0.0001128336,0.00149249,0.005294232,0.0003030623,0.002533023,0.1285882],"study_design_scores_gemma":[0.3442735,0.6117436,0.03094286,0.0001213059,0.002267505,0.000410008,0.0001588846,0.003315467,0.002519545,0.0005841777,0.003606691,0.00005648052],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932504,0.003865497,0.0001889598,0.0003412117,0.0001168027,0.0002999811,0.0003571456,0.000046405,0.001533724],"genre_scores_gemma":[0.9975703,0.0007751122,0.0002440303,0.0002418142,0.00006778759,0.000243843,0.0003071045,0.000004971452,0.000544845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003549705,"threshold_uncertainty_score":0.01187491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620111452566371,"score_gpt":0.2885031783780858,"score_spread":0.2723020638524221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}