{"id":"W2989904783","doi":"10.1093/neuonc/noz219.1199","title":"LTBK-08. TOCA 511 & TOCA FC VERSUS STANDARD OF CARE IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; University of Alberta; Montreal Neurological Institute and Hospital; University Health Network; CancerCare Manitoba; Sunnybrook Hospital; Ottawa Regional Cancer Foundation; Princess Margaret Cancer Centre","funders":"","keywords":"Temozolomide; Medicine; Clinical endpoint; Internal medicine; Interim analysis; Oncology; Adverse effect; Bevacizumab; Progression-free survival; Glioma; Lomustine; Gastroenterology; Surgery; Randomized controlled trial; Chemotherapy; Cyclophosphamide; Cancer research; Vincristine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006350819,0.0002378791,0.0007274809,0.0002442784,0.00002883738,0.000006745808,0.0001123913,0.000162534,0.0002191951],"category_scores_gemma":[0.00008060196,0.0001821746,0.00009288764,0.0003321274,0.00007052766,0.00005113929,0.00007582897,0.0002375592,0.00009643158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005532212,"about_ca_system_score_gemma":0.0002352085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003213838,"about_ca_topic_score_gemma":0.004702723,"domain_scores_codex":[0.9982898,0.0001229228,0.0003687168,0.0004427018,0.0004128824,0.0003629833],"domain_scores_gemma":[0.9987175,0.0002635097,0.0001870681,0.0004720813,0.0002078431,0.0001519927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5719398,0.004820504,0.3594126,0.0003447164,0.000318888,0.0007211649,0.002130708,0.0000750429,0.003027257,0.0005193606,0.004114921,0.05257505],"study_design_scores_gemma":[0.06556551,0.6585858,0.1533025,0.000220867,0.0003367879,0.00002277013,0.0003463512,0.000004355741,0.01400617,0.00002312358,0.1072818,0.0003039725],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949501,0.0002702242,3.009719e-7,0.0009199582,0.001188697,0.001419007,0.0001076714,0.00003178883,0.001112211],"genre_scores_gemma":[0.999148,0.00003741175,0.0002659576,0.0001692718,0.00005463366,0.0001059606,0.0001799876,0.00003393617,0.000004840215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6537653,"threshold_uncertainty_score":0.7428863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620111452566371,"score_gpt":0.2885031783780858,"score_spread":0.2723020638524221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}