{"id":"W2989937144","doi":"10.1080/14740338.2020.1698545","title":"The clozapine to norclozapine ratio: a narrative review of the clinical utility to minimize metabolic risk and enhance clozapine efficacy","year":2019,"lang":"en","type":"review","venue":"Expert Opinion on Drug Safety","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diabetes Canada; McMaster University; University of Toronto; Centre for Addiction and Mental Health","funders":"National Research Foundation of Korea; Lundbeckfonden","keywords":"Clozapine; Medicine; Pharmacology; Internal medicine; Intensive care medicine; Schizophrenia (object-oriented programming); Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002548065,0.0008367402,0.001743552,0.002849789,0.0002557442,0.001503643,0.0009886388,0.0009894765,0.003664993],"category_scores_gemma":[0.01003704,0.0002811224,0.001633132,0.002741761,0.0004404576,0.001142264,0.0006545921,0.00109427,0.0004918032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001202991,"about_ca_system_score_gemma":0.003829012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003051162,"about_ca_topic_score_gemma":0.007127014,"domain_scores_codex":[0.9988731,0.0003426686,0.0003560109,0.0001346108,0.0002480632,0.00004558243],"domain_scores_gemma":[0.9941769,0.004176181,0.0009035328,0.00006245719,0.0006080471,0.00007287814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002827098,0.00002910911,0.0004256181,0.446996,0.001086142,0.0001809899,0.0003014854,0.0002616269,0.0003749236,0.002878881,0.02720326,0.5199793],"study_design_scores_gemma":[0.0001273355,0.0002453931,0.004023331,0.540198,0.007302349,0.001675982,0.0004068795,0.0002573029,0.0003782194,0.002658165,0.4426671,0.00005985722],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001358325,0.9989261,0.00004478453,0.0004728899,0.00009910927,0.00001129235,0.0000614808,0.000002957242,0.0002454791],"genre_scores_gemma":[0.002057518,0.9970667,0.0001435654,0.0004355859,0.0001210722,0.00002328183,0.00005972853,0.000001848147,0.00009073286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003664993,"threshold_uncertainty_score":0.01347566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07745435242841285,"score_gpt":0.459064430117643,"score_spread":0.3816100776892302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}