{"id":"W2989960243","doi":"10.1167/iovs.19-27512","title":"Role of Translational Attenuation in Inherited Retinal Degeneration","year":2019,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Eye Institute","keywords":"Anisomycin; Retinal degeneration; Retinal; Protein biosynthesis; Retina; Biology; Cell biology; Neurodegeneration; PI3K/AKT/mTOR pathway; Signal transduction; Internal medicine; Neuroscience; Molecular biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004155115,0.00009300114,0.0001032375,0.0001139732,0.00004930601,0.00000952092,0.0001617178,0.00008309392,0.00005645348],"category_scores_gemma":[0.0001368323,0.00009264249,0.00002478309,0.0004439668,0.0006950325,0.00002055666,0.00004406892,0.00006252156,0.0000140409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001440067,"about_ca_system_score_gemma":0.0002856828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003337088,"about_ca_topic_score_gemma":0.00001001099,"domain_scores_codex":[0.9989908,0.00007975929,0.0002140128,0.0003244638,0.0002119779,0.0001789993],"domain_scores_gemma":[0.9996067,0.00001478554,0.00009607891,0.00009150091,0.0001396154,0.00005131719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000317224,0.00002235777,0.3521261,0.00000285869,0.000001858663,5.643059e-7,0.0001661725,0.0001030106,0.6472958,0.0001276648,0.000002580333,0.0001193674],"study_design_scores_gemma":[0.0001901959,0.0001925369,0.4732682,0.000008649003,0.000001162939,0.000008677987,0.0001189266,0.0004098404,0.5244797,0.001227889,0.00002227169,0.00007197358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970267,0.00007946048,0.00000680771,0.000103956,0.00005703538,0.0001801951,0.000002281891,0.000002968483,0.002540584],"genre_scores_gemma":[0.9985694,0.000003404741,0.00116744,0.00005222422,0.00001838532,0.00001208882,0.00006105834,0.000005161771,0.0001108425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1228161,"threshold_uncertainty_score":0.3777851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789237917470716,"score_gpt":0.2974783897529197,"score_spread":0.2795860105782125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}