{"id":"W2990020721","doi":"10.1101/851527","title":"Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4 <sup>+</sup> T cells","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Université de Recherche Paris Sciences et Lettres; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Labex CelTisPhyBio; Infrastructures en Biologie Santé et Agronomie","keywords":"Antigen presentation; Priming (agriculture); Cell biology; Antigen processing; Antigen; Antigen-presenting cell; Biology; Compartment (ship); T cell; B cell; Immunology; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061508,0.0002784453,0.0001708374,0.0001026119,0.0001349805,0.0002951976,0.0001377306,0.000314722,0.00177852],"category_scores_gemma":[0.0001175671,0.0001096529,0.0001523694,0.0000861291,0.0002064953,0.0002551448,0.0002123222,0.0005361821,0.001041919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810024,"about_ca_system_score_gemma":0.0001754385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002388635,"about_ca_topic_score_gemma":0.0002151225,"domain_scores_codex":[0.9999129,0.00000878939,0.000007135222,0.00001902207,0.00002524994,0.000026867],"domain_scores_gemma":[0.9999173,0.00000851938,0.00002696936,0.00001317671,0.00001296867,0.00002107061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005347417,0.000003581272,0.0001429146,0.00001224707,0.000001163759,0.00003242816,0.000004586637,0.00002170748,0.999339,0.00010702,0.00003670025,0.0002450446],"study_design_scores_gemma":[0.00002118119,0.00005273844,0.005753954,0.000005983505,0.000005002667,0.0002971792,0.00005061525,0.0006396924,0.9896348,0.0001755568,0.003359933,0.000003267179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926092,0.0006183953,0.003716172,0.0002099378,0.00004872882,0.00001749783,0.0007393971,0.00009783726,0.001942848],"genre_scores_gemma":[0.991797,0.000388092,0.003414242,0.00008650497,0.00002141308,0.00002521372,0.0008761612,0.00005923238,0.003332235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177852,"threshold_uncertainty_score":0.005949736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692451197751738,"score_gpt":0.2298756092397821,"score_spread":0.2129510972622647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}