{"id":"W2990060701","doi":"10.1016/j.jacbts.2019.07.004","title":"CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage","year":2019,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Heart and Stroke Foundation; Sunnybrook Health Science Centre; St. Michael's Hospital; Princess Margaret Cancer Centre; University of Toronto; Toronto General Hospital; University Health Network; Ted Rogers Centre for Heart Research","funders":"Northwell Health; Connaught Fund; Royal Swedish Academy of Sciences; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; Lunds Universitet; Canada Research Chairs; Canadian Institutes of Health Research; Ontario Council on Graduate Studies, Council of Ontario Universities; Brain Aneurysm Foundation; Tampa Bay Estuary Program; Heart and Stroke Foundation of Canada","keywords":"Medicine; Subarachnoid hemorrhage; Perfusion; Cardiology; Cerebral blood flow; Heart failure; Internal medicine; Cerebral perfusion pressure; Stroke (engine); Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004890343,0.0007529344,0.0007804887,0.001240304,0.0004209334,0.0005068859,0.0005477964,0.000922868,0.00234857],"category_scores_gemma":[0.0002252565,0.0002646561,0.0005637998,0.0003064271,0.0007395793,0.0005583711,0.0003147754,0.001776528,0.0005074235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006019007,"about_ca_system_score_gemma":0.0007444953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625465,"about_ca_topic_score_gemma":0.003199707,"domain_scores_codex":[0.9996036,0.00007038093,0.00004691548,0.00006016757,0.0001022015,0.0001166538],"domain_scores_gemma":[0.9996626,0.00002441712,0.0001209619,0.00002920366,0.00003818722,0.000124604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001488013,0.0005849157,0.0002684579,0.0001744079,0.00004567378,0.0003231162,0.00005950278,0.0002298992,0.9884703,0.0005346399,0.0008757999,0.006945119],"study_design_scores_gemma":[0.0005299233,0.005550965,0.006707025,0.00008771569,0.0001506057,0.0006584381,0.0001682368,0.002116935,0.9764614,0.0004349948,0.007102217,0.00003163721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764605,0.005037012,0.008225068,0.001751494,0.0004454528,0.0002705187,0.002524333,0.001138563,0.004147063],"genre_scores_gemma":[0.9786834,0.006225082,0.005668434,0.0005531836,0.0001167397,0.000508501,0.00155924,0.0001320204,0.006553356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234857,"threshold_uncertainty_score":0.007856727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846375129360435,"score_gpt":0.2861685926019684,"score_spread":0.2677048413083641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}