{"id":"W2990060701","doi":"10.1016/j.jacbts.2019.07.004","title":"CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage","year":2019,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Heart and Stroke Foundation; Sunnybrook Health Science Centre; St. Michael's Hospital; Princess Margaret Cancer Centre; University of Toronto; Toronto General Hospital; University Health Network; Ted Rogers Centre for Heart Research","funders":"Northwell Health; Connaught Fund; Royal Swedish Academy of Sciences; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; Lunds Universitet; Canada Research Chairs; Canadian Institutes of Health Research; Ontario Council on Graduate Studies, Council of Ontario Universities; Brain Aneurysm Foundation; Tampa Bay Estuary Program; Heart and Stroke Foundation of Canada","keywords":"Medicine; Subarachnoid hemorrhage; Perfusion; Cardiology; Cerebral blood flow; Heart failure; Internal medicine; Cerebral perfusion pressure; Stroke (engine); Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004804362,0.0001108497,0.0002062892,0.0002725457,0.00006639879,0.00002596117,0.0001608883,0.00004573008,0.0001029759],"category_scores_gemma":[0.00004428453,0.00009304373,0.00003544299,0.0007687776,0.0002328077,0.0005013592,0.00004098993,0.0001567811,0.00001814779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004643217,"about_ca_system_score_gemma":0.0002715693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007586022,"about_ca_topic_score_gemma":0.00008278989,"domain_scores_codex":[0.9981551,0.00002362771,0.0002413223,0.0003507498,0.0009095609,0.0003196972],"domain_scores_gemma":[0.9993454,0.0001134421,0.00003222673,0.000208493,0.000144315,0.0001561411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003125592,0.000117057,0.1576657,0.000149963,0.000001916222,0.00000270412,0.000754418,0.005371484,0.8270831,0.002076485,0.000007393278,0.006457264],"study_design_scores_gemma":[0.00343547,0.0007915783,0.6027507,0.0001514979,0.00002079716,0.00008981748,0.0004217147,0.2645724,0.1242368,0.002491391,0.0006545188,0.0003833444],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934202,0.0001982374,0.001623589,0.003707627,0.00002774993,0.0005601624,0.00002771089,0.00001619291,0.00041854],"genre_scores_gemma":[0.9588408,0.000003317092,0.04074858,0.0002478301,0.00001496332,0.000008598538,0.000005802768,0.000009023704,0.0001211266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7028463,"threshold_uncertainty_score":0.3794213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846375129360435,"score_gpt":0.2861685926019684,"score_spread":0.2677048413083641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}