{"id":"W2990072706","doi":"10.3390/pharmaceutics11120626","title":"Repeat-Dose Toxicity Study Using the AFPL1-Conjugate Nicotine Vaccine in Male Sprague Dawley Rats","year":2019,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Laurentian University; Health Sciences North","funders":"Canadian Institutes of Health Research","keywords":"Nicotine; Medicine; Heterologous; Toxicity; Vaccination; Dosing; Pharmacology; Immunization; Hematology; Histopathology; Immunology; Physiology; Antibody; Internal medicine; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006683408,0.00116095,0.0006892416,0.0008789896,0.0003321002,0.0002914854,0.0004250941,0.000966246,0.001080845],"category_scores_gemma":[0.0003115664,0.0003322129,0.0008870989,0.0003130489,0.0005843112,0.0005073751,0.000230045,0.001615853,0.0003393673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000443315,"about_ca_system_score_gemma":0.0005889082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968605,"about_ca_topic_score_gemma":0.002822512,"domain_scores_codex":[0.9995899,0.00007766236,0.00003358959,0.0001171502,0.00008549201,0.00009627419],"domain_scores_gemma":[0.9992411,0.00012725,0.0002217291,0.0001222546,0.0001521326,0.0001355515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001988625,0.003838276,0.001017306,0.00005696214,0.00003558326,0.0001529353,0.0001201633,0.0004375329,0.9892815,0.0001024182,0.00009586103,0.002872676],"study_design_scores_gemma":[0.0001675619,0.09198191,0.005676881,0.00001140064,0.0001295761,0.000280168,0.0001244103,0.001662079,0.8990167,0.0000995599,0.0008198626,0.00002998049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953232,0.0003303085,0.002992388,0.00008018433,0.00007125916,0.0001920604,0.0003508683,0.00008526214,0.0005744162],"genre_scores_gemma":[0.9844723,0.001320856,0.005307674,0.0001816612,0.00007139103,0.0004169338,0.0009372713,0.00004951767,0.00724244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968605,"threshold_uncertainty_score":0.003914356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04445023892724542,"score_gpt":0.3378207395860448,"score_spread":0.2933705006587994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}