{"id":"W2990080596","doi":"10.1016/j.chest.2019.11.009","title":"Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease","year":2019,"lang":"en","type":"review","venue":"CHEST Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Canadian Pulmonary Fibrosis Foundation; Gilead Sciences","keywords":"Proteostasis; Unfolded protein response; Endoplasmic reticulum; Medicine; Disease; Lung; Population; Bioinformatics; Immunology; Cell biology; Pathology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002123251,0.0005094988,0.0008659121,0.0001636157,0.0001005287,0.0001626912,0.0003512153,0.0003195299,0.0000429984],"category_scores_gemma":[0.000170013,0.0004198673,0.000413469,0.0001126793,0.0001054838,0.00001030199,0.000213733,0.0006285286,0.0000141924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001616752,"about_ca_system_score_gemma":0.001218864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004229398,"about_ca_topic_score_gemma":0.000008460984,"domain_scores_codex":[0.9978274,0.0001932146,0.0006239868,0.0006051076,0.0002248605,0.0005254185],"domain_scores_gemma":[0.9985619,0.00002687529,0.0004117273,0.0004509953,0.00004880704,0.0004996684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002493047,0.0004906225,0.004561026,0.2058468,0.0009237966,0.002320185,0.00007679906,0.0001818096,0.002905646,0.0002221343,0.002472129,0.7797497],"study_design_scores_gemma":[0.001404295,0.0001237951,0.0001193726,0.03005829,0.0008083771,0.0004379174,0.00003062652,0.0002071044,0.0006288441,0.00003155062,0.9651799,0.0009699836],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01195256,0.9866782,0.00003909006,0.00002462038,0.0002212967,0.000748828,0.0001058092,0.000007355697,0.0002222787],"genre_scores_gemma":[0.008133125,0.9901488,0.00006290182,0.00001477011,0.0007396351,0.00009249519,0.0001915881,0.00007917838,0.0005375082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9627077,"threshold_uncertainty_score":0.9998253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932832709136684,"score_gpt":0.2996114361955297,"score_spread":0.2802831091041628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}