{"id":"W2990090865","doi":"10.1126/scisignal.aax3194","title":"Sequential activation of STIM1 links Ca <sup>2+</sup> with luminal domain unfolding","year":2019,"lang":"en","type":"article","venue":"Science Signaling","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Western University","funders":"Interreg; National Research Council Canada; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Austrian Science Fund; Grantová Agentura České Republiky; Johannes Kepler Universität Linz","keywords":"Domain (mathematical analysis); Chemistry; STIM1; Cell biology; Endoplasmic reticulum; Physics; Biophysics; Crystallography; Biology; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007444661,0.0001410867,0.0001689956,0.0002544746,0.000346661,0.000101633,0.0004488917,0.00008345374,0.0002655939],"category_scores_gemma":[0.0001353793,0.0001061628,0.00005084006,0.001197346,0.0005595734,0.0007147746,0.00009046557,0.0002670001,0.00005326097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008069222,"about_ca_system_score_gemma":0.0002872119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004476482,"about_ca_topic_score_gemma":3.550747e-7,"domain_scores_codex":[0.9978561,0.00005848638,0.0002374579,0.0005247307,0.0008939294,0.0004293269],"domain_scores_gemma":[0.9993178,0.0001179912,0.0001732066,0.0001705255,0.0001147743,0.0001057441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002932532,0.00002071548,0.0001488087,0.00001929257,0.000001337335,0.000002174657,0.001758293,0.07813352,0.9189743,0.0006115239,0.000009759759,0.0002909729],"study_design_scores_gemma":[0.0002877139,0.0001639547,0.00001167557,0.0001347954,0.000004196239,0.00001226673,0.0015421,0.03669043,0.9606535,0.0002250488,0.0001185675,0.0001557775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946531,0.000004364702,0.003286097,0.0001308272,0.0004017595,0.0002291632,0.000003751549,0.0000377682,0.001253141],"genre_scores_gemma":[0.9983792,0.000001585496,0.001112509,0.0001289214,0.0001641504,0.000003989333,0.00000105832,0.0000127244,0.000195808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0416792,"threshold_uncertainty_score":0.4329193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223402315278646,"score_gpt":0.2616988390754043,"score_spread":0.2394648159226178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}