{"id":"W2990095900","doi":"10.1016/j.jaad.2019.06.1313","title":"DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: Pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2)","year":2019,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Revance","keywords":"Medicine; Placebo; Adverse effect; Wrinkle; Multicenter study; Placebo response; Randomized controlled trial; Internal medicine; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02384777,0.001726069,0.004834393,0.001232611,0.0005264221,0.001713304,0.0006816257,0.001447244,0.004920829],"category_scores_gemma":[0.01553443,0.0007375294,0.01156429,0.001575604,0.0008010138,0.001173511,0.0008355603,0.001357476,0.0003723799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007925402,"about_ca_system_score_gemma":0.001074623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599827,"about_ca_topic_score_gemma":0.001482642,"domain_scores_codex":[0.9885958,0.006451942,0.001998885,0.001230008,0.001330824,0.0003925789],"domain_scores_gemma":[0.9767319,0.01123781,0.008460284,0.001375463,0.001492186,0.0007023225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6568859,0.002201577,0.01986955,0.02639546,0.1938784,0.0001163282,0.0002042832,0.0008394817,0.009761279,0.0001548349,0.002727023,0.08696586],"study_design_scores_gemma":[0.3320833,0.1459893,0.1907672,0.003384423,0.308415,0.0007607585,0.0002281834,0.0009834577,0.006243449,0.0004653047,0.01046984,0.0002098262],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.59467,0.3834419,0.0048774,0.001174848,0.001195031,0.004219693,0.005988021,0.0003168039,0.00411628],"genre_scores_gemma":[0.9537262,0.0373113,0.002117344,0.001112363,0.0007786673,0.001682813,0.002576274,0.00007288402,0.0006220756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02384777,"threshold_uncertainty_score":0.1261206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07944808609675488,"score_gpt":0.3954953100959513,"score_spread":0.3160472239991965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}