{"id":"W2990147736","doi":"10.1093/nar/gkz1115","title":"Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid–siRNA conjugates","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Gene silencing; Folic acid; Transfection; Gene; Biochemistry; Molecular biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004341475,0.0001670614,0.0002425757,0.0001192955,0.00009764487,0.00003860838,0.0003440304,0.000223669,0.0001111682],"category_scores_gemma":[0.00009689506,0.000158711,0.0000866831,0.0001592633,0.0002021944,0.00001782687,0.0003319488,0.0002586631,0.00005249232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000272764,"about_ca_system_score_gemma":0.0001509291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00014335,"about_ca_topic_score_gemma":0.00002333404,"domain_scores_codex":[0.998243,0.000166796,0.0002117825,0.000496078,0.000361688,0.0005206771],"domain_scores_gemma":[0.9989256,0.00003925603,0.00007029041,0.0004718221,0.0003604929,0.0001324998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004053626,0.00005776529,0.001887789,0.00005067953,0.00007211265,0.000002562342,0.0001837557,0.00003040812,0.9912201,0.00002697745,0.00027983,0.005782702],"study_design_scores_gemma":[0.00061613,0.0007007559,0.009290359,0.00003374666,0.000006932091,0.000004650941,0.0001863659,0.0005351915,0.9882016,0.00006645727,0.0001897723,0.0001680767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967567,0.0009051071,0.0002012358,0.00005129242,0.00009463733,0.0003011538,0.00002965841,0.00001149171,0.001648771],"genre_scores_gemma":[0.9978527,0.001119416,0.0002042621,0.00005268463,0.00009425405,0.00001441684,0.00003099779,0.00002558062,0.0006056608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00740257,"threshold_uncertainty_score":0.6472046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02523349198117234,"score_gpt":0.2961162219854165,"score_spread":0.2708827300042442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}