{"id":"W2990147736","doi":"10.1093/nar/gkz1115","title":"Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid–siRNA conjugates","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Gene silencing; Folic acid; Transfection; Gene; Biochemistry; Molecular biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657686,0.0004532927,0.000543479,0.0002279996,0.0001661972,0.0002818475,0.0002416799,0.0004732894,0.000645215],"category_scores_gemma":[0.0001534548,0.00018146,0.0002696766,0.0001931638,0.0002545573,0.0002050908,0.0001848825,0.0005284396,0.0002879981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000454767,"about_ca_system_score_gemma":0.000235335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007225809,"about_ca_topic_score_gemma":0.001217608,"domain_scores_codex":[0.9998593,0.00002328557,0.00001275397,0.00004274369,0.00003139929,0.00003050916],"domain_scores_gemma":[0.9998875,0.00001805295,0.00004411278,0.00001169802,0.00001959753,0.00001908442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001599989,0.000003952466,0.00001509745,0.00001586894,0.00000276169,0.00002603351,0.000006960497,0.00004765613,0.9993363,0.00004431534,0.00001071726,0.0004743545],"study_design_scores_gemma":[0.000003696568,0.00008645677,0.0001427276,0.000001105255,0.000005952543,0.00005463999,0.000001863003,0.0002533856,0.9989597,0.000006520043,0.0004818212,0.000002175198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814154,0.001974657,0.01435952,0.0001032674,0.00003622738,0.00005872046,0.0001794409,0.0001816341,0.001691128],"genre_scores_gemma":[0.9869251,0.0007465265,0.01001913,0.00004742816,0.00001353806,0.00004118531,0.0001909478,0.00003289921,0.001983267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007225809,"threshold_uncertainty_score":0.003299594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02523349198117234,"score_gpt":0.2961162219854165,"score_spread":0.2708827300042442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}