{"id":"W2990151550","doi":"10.1101/855486","title":"Lysates of <i>Methylococcus capsulatus</i> Bath induce a lean-like microbiota, intestinal FoxP3 <sup>+</sup> RORγt <sup>+</sup> IL-17 <sup>+</sup> Tregs and improve metabolism","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Norges Forskningsråd; Canada First Research Excellence Fund; Novo Nordisk Fonden; Novo Nordisk; H. Lundbeck A/S; Lundbeckfonden","keywords":"Homeostasis; Gut flora; Immune system; Biology; Metabolism; FOXP3; Bacteria; Chemistry; Endocrinology; Microbiology; Internal medicine; Biochemistry; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207395,0.0004149117,0.0001975237,0.000163045,0.00009059889,0.0002300503,0.0001187974,0.0002385881,0.001607311],"category_scores_gemma":[0.000066619,0.00009230381,0.0001916152,0.00009350957,0.0001926908,0.0000970543,0.000199488,0.0004908625,0.0004147095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001364312,"about_ca_system_score_gemma":0.0001471311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006378869,"about_ca_topic_score_gemma":0.0007172648,"domain_scores_codex":[0.9998918,0.00001821617,0.0000081372,0.0000219309,0.00003207888,0.00002789929],"domain_scores_gemma":[0.9999417,0.00000571393,0.00001913163,0.000009596989,0.000005950643,0.00001789083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009016699,0.00001679516,0.0001427385,0.00001556266,0.000002646682,0.00001127029,0.000003856997,0.00001854444,0.9992626,0.00001671225,0.00002413844,0.0003949932],"study_design_scores_gemma":[0.000007938703,0.0002084907,0.004563218,0.000005397213,0.000005604939,0.00006584106,0.00001642565,0.0001952673,0.9939174,0.00002004415,0.0009923762,0.000001951774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925841,0.0009824331,0.003188452,0.0002263146,0.00006100709,0.00003096487,0.0009682523,0.0001245403,0.001833902],"genre_scores_gemma":[0.9872168,0.000493421,0.004314658,0.0001568016,0.00002184421,0.00004419689,0.00153229,0.00006644123,0.00615358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607311,"threshold_uncertainty_score":0.005376935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009060890410047493,"score_gpt":0.2186907180674547,"score_spread":0.2096298276574072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}