{"id":"W2990157072","doi":"10.1101/861955","title":"Signaling compartment at the ciliary tip is formed and maintained by intraflagellar transport and functions as sensitive salt detector","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology; Michael Smith Health Research BC","keywords":"Cilium; Intraflagellar transport; Cell biology; Ciliopathies; Axoneme; Biology; Compartment (ship); Organelle; Signal transduction; Bardet–Biedl syndrome; Flagellum; Biochemistry; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007744839,0.0002699428,0.0002873054,0.000246288,0.0003318729,0.0005410508,0.0002185688,0.0005349674,0.001504045],"category_scores_gemma":[0.0001080649,0.0001617223,0.0002167812,0.0001041595,0.0003801718,0.0002808968,0.0004942856,0.0005181592,0.0008611119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005812626,"about_ca_system_score_gemma":0.0004238175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00156113,"about_ca_topic_score_gemma":0.00147877,"domain_scores_codex":[0.9998671,0.000006852472,0.000005415094,0.0000472666,0.00004383786,0.00002959626],"domain_scores_gemma":[0.999913,0.000004205404,0.00001713863,0.00001601227,0.00001554846,0.00003416817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003027215,0.000003440846,0.0003080694,0.00001174114,0.000001586224,0.0001053445,0.000008372933,0.00003532328,0.9982798,0.0004205163,0.00005800671,0.0007375074],"study_design_scores_gemma":[0.00000843859,0.00003093297,0.01164095,0.000008344207,0.000006693247,0.0005778486,0.00003260888,0.00232752,0.9806621,0.0002441024,0.004454586,0.000005872238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802601,0.00115758,0.01093112,0.0003574555,0.0001247572,0.0000222561,0.0006206515,0.0003486813,0.006177374],"genre_scores_gemma":[0.9830634,0.0003298936,0.004668544,0.00005337502,0.00001223113,0.00001362429,0.0004593364,0.00006303002,0.01133649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156113,"threshold_uncertainty_score":0.005031466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005527488391951867,"score_gpt":0.1951625178633455,"score_spread":0.1896350294713937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}