{"id":"W2990162620","doi":"10.1371/journal.pntd.0007490","title":"Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model","year":2019,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Schistosoma mansoni; Biology; Salmonella enterica; Microbiology; Cathepsin B; Schistosoma; Cathepsin; Immunology; Cathepsin L; Cathepsin D; Intestinal mucosa; Salmonella; Andrology; Virology; Schistosomiasis; Enzyme; Medicine; Internal medicine; Helminths; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003379734,0.0009056691,0.0006308299,0.0006833291,0.0001905094,0.0003545516,0.0003564799,0.0008773249,0.002022273],"category_scores_gemma":[0.0001330156,0.0004322873,0.0006315593,0.0002575547,0.0004359856,0.0003833355,0.0002247271,0.001891146,0.0007492676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002867958,"about_ca_system_score_gemma":0.0003205744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009025572,"about_ca_topic_score_gemma":0.001234223,"domain_scores_codex":[0.9996712,0.00004387611,0.00004080299,0.00007922799,0.00007110395,0.00009380389],"domain_scores_gemma":[0.999739,0.00002181441,0.00008334677,0.00002631123,0.00002321045,0.0001063113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009845808,0.0005573818,0.0002015428,0.00008624669,0.00001398783,0.00005389686,0.00002849343,0.00008383042,0.9965646,0.00007909061,0.0001506295,0.00119574],"study_design_scores_gemma":[0.0003380003,0.01527459,0.005819417,0.00003767138,0.00006897497,0.000463166,0.00006982451,0.001237518,0.9730865,0.00006229011,0.003525218,0.00001675088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930568,0.0008611541,0.002046084,0.0002892155,0.0001361762,0.0001831978,0.001366475,0.0003386565,0.001722206],"genre_scores_gemma":[0.9818568,0.001439145,0.003317518,0.0002056607,0.000043863,0.0002593052,0.002845063,0.00006915646,0.00996348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022273,"threshold_uncertainty_score":0.006765127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.029466541461561,"score_gpt":0.2549555644841664,"score_spread":0.2254890230226054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}