{"id":"W2990162620","doi":"10.1371/journal.pntd.0007490","title":"Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model","year":2019,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Schistosoma mansoni; Biology; Salmonella enterica; Microbiology; Cathepsin B; Schistosoma; Cathepsin; Immunology; Cathepsin L; Cathepsin D; Intestinal mucosa; Salmonella; Andrology; Virology; Schistosomiasis; Enzyme; Medicine; Internal medicine; Helminths; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000006787861,0.0003052848,0.0003634845,0.0001960811,0.0003102602,0.00005436536,0.0002576149,0.0001822972,0.0001084412],"category_scores_gemma":[0.0001995127,0.0002400163,0.0001539131,0.0002594081,0.00009816048,0.0002233996,0.00009047355,0.0005086778,0.000250261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310798,"about_ca_system_score_gemma":0.0001226856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001387426,"about_ca_topic_score_gemma":0.0001531482,"domain_scores_codex":[0.9981965,0.0003474145,0.0003815509,0.0005191225,0.00009482725,0.0004605774],"domain_scores_gemma":[0.9990643,0.0001745304,0.0001838464,0.0003756365,0.0001442252,0.00005750035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007849886,0.001356767,0.003345243,0.00005975384,0.0001773758,0.0000156003,0.0004549522,0.001564687,0.9913835,0.0002064245,0.00007613344,0.0005745655],"study_design_scores_gemma":[0.005475562,0.001055975,0.7177489,0.0005941291,0.0003670618,0.00007176172,0.0005010485,0.2351163,0.03488742,0.0002917252,0.002647811,0.001242359],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948177,0.001309452,0.0005754171,0.0009092652,0.000207924,0.001438315,0.0003313775,0.0001609923,0.000249503],"genre_scores_gemma":[0.9983982,0.0001220549,0.0000669514,0.0001726025,0.00005483962,0.0002481579,0.0002734289,0.00004145467,0.0006222642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9564961,"threshold_uncertainty_score":0.978758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.029466541461561,"score_gpt":0.2549555644841664,"score_spread":0.2254890230226054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}