{"id":"W2990232535","doi":"10.1182/blood-2019-121996","title":"Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Biology; Stem cell; Cancer research; Leukemia; Embryonic stem cell; Myeloid leukemia; Fusion protein; Immunology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115854,0.0002026308,0.0002026686,0.0003822979,0.00008428569,0.000279755,0.0001551471,0.0001988749,0.001286273],"category_scores_gemma":[0.0001029537,0.0001157471,0.0002157784,0.0002671133,0.0001866736,0.0001808349,0.0001996832,0.0006704617,0.0002910091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272712,"about_ca_system_score_gemma":0.0001777592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005683762,"about_ca_topic_score_gemma":0.0006624995,"domain_scores_codex":[0.999855,0.00001268182,0.00002088858,0.00002213445,0.00005332874,0.00003603293],"domain_scores_gemma":[0.9998915,0.00002159917,0.00003382903,0.0000107095,0.000005901455,0.00003629135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001741395,0.00004054357,0.000364146,0.00001716184,0.000004734947,0.00002822123,0.00001240219,0.0001440288,0.9979005,0.00009056796,0.00004405528,0.001179418],"study_design_scores_gemma":[0.00001680338,0.000320174,0.008274767,0.000004852303,0.00001386183,0.00009947836,0.00003439592,0.001677345,0.9877807,0.00008753187,0.001686112,0.000003863955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975218,0.0002554152,0.000577123,0.0000521811,0.00001078617,0.000009245415,0.001000735,0.00006648889,0.0005061445],"genre_scores_gemma":[0.9954411,0.0003554169,0.0005632561,0.00004058502,0.000002899616,0.00002475966,0.001606148,0.00001956792,0.001946193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286273,"threshold_uncertainty_score":0.004302979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256435116694218,"score_gpt":0.2529463441477112,"score_spread":0.240381992980769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}