{"id":"W2990258587","doi":"10.1534/g3.119.400199","title":"An sRNA Screen for Reversal of Quinolone Resistance in <i>Escherichia coli</i>","year":2019,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Biology; DNA gyrase; Escherichia coli; Ciprofloxacin; Efflux; Gene; Genetics; Gene knockdown; Antibiotic resistance; Transfer RNA; Computational biology; Microbiology; Antibiotics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003109952,0.000421772,0.0004920686,0.0004659531,0.0001839794,0.0003407304,0.0003293021,0.0004751466,0.00190659],"category_scores_gemma":[0.0003396054,0.0001792258,0.0004183257,0.0002019432,0.0002855901,0.0001171653,0.000251187,0.0004718481,0.0008650372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003048222,"about_ca_system_score_gemma":0.000278071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007335792,"about_ca_topic_score_gemma":0.001654251,"domain_scores_codex":[0.9996307,0.00005418202,0.00004030007,0.00008676347,0.0001436237,0.00004449043],"domain_scores_gemma":[0.9996624,0.00009753668,0.00008797514,0.00003613176,0.00006689701,0.00004915409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001611674,0.00001309303,0.00007418136,0.0000155507,0.000002242441,0.00002095059,0.000003845571,0.00003915426,0.9991224,0.0000230742,0.00002436384,0.0006449824],"study_design_scores_gemma":[0.00001168541,0.000358536,0.001678516,0.000004324473,0.00001643613,0.0002163696,0.00001706953,0.0007976962,0.9951963,0.00001877684,0.001678013,0.000006355635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398226,0.001554723,0.04756682,0.0004785724,0.000108196,0.0006311333,0.002982572,0.001608805,0.005246494],"genre_scores_gemma":[0.9353761,0.0008661822,0.05154177,0.0003883075,0.00001755626,0.0002070261,0.004099503,0.0003129947,0.007190602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00190659,"threshold_uncertainty_score":0.006378233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006210047619195,"score_gpt":0.2513433642990778,"score_spread":0.2412812638228858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}