{"id":"W2990280940","doi":"10.1002/btpr.2942","title":"SH‐SY5Y and LUHMES cells display differential sensitivity to MPP+, tunicamycin, and epoxomicin in 2D and 3D cell culture","year":2019,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation; Nova Scotia Health Research Foundation; Beatrice Hunter Cancer Research Institute","keywords":"Tunicamycin; Cell culture; SH-SY5Y; Neurotoxicity; Toxicant; Biology; Toxicology; Cell biology; Cell growth; Viability assay; Toxicity; Biochemistry; Apoptosis; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008840277,0.0002115376,0.0002605378,0.0001951348,0.00008357188,0.00006782461,0.0001529073,0.0002553908,0.000002110504],"category_scores_gemma":[0.00005448734,0.0001739592,0.00001669082,0.000274744,0.0003968389,0.0001482449,0.0004421188,0.0003477453,0.00000906266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001198932,"about_ca_system_score_gemma":0.000007159276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007662501,"about_ca_topic_score_gemma":0.000010099,"domain_scores_codex":[0.9985501,0.00005510967,0.0001515376,0.0007366673,0.0001161936,0.0003904353],"domain_scores_gemma":[0.9995061,0.00007934289,0.00004720708,0.000259865,0.00000666107,0.0001008058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002386826,0.00003856407,0.00398272,0.00005409101,7.034889e-7,0.00007955542,0.0001021573,0.00000441833,0.992357,0.000303347,0.00001223019,0.003041338],"study_design_scores_gemma":[0.0004410324,0.0002311701,0.007259627,0.00004267501,0.000005489054,0.000111385,0.00003573706,0.003653889,0.9873033,0.00001981809,0.0006789535,0.0002169763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979774,0.0002022146,0.00003754643,0.0009371191,0.000222914,0.0004558557,0.00001245269,0.0001279889,0.00002652389],"genre_scores_gemma":[0.9989775,0.0004115175,0.0002003852,0.0002285059,0.00001432644,0.00001005995,3.879672e-7,0.00001547772,0.0001418014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00505376,"threshold_uncertainty_score":0.7093849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007775886752062883,"score_gpt":0.2263593815030078,"score_spread":0.2185834947509449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}