{"id":"W2990280940","doi":"10.1002/btpr.2942","title":"SH‐SY5Y and LUHMES cells display differential sensitivity to MPP+, tunicamycin, and epoxomicin in 2D and 3D cell culture","year":2019,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation; Nova Scotia Health Research Foundation; Beatrice Hunter Cancer Research Institute","keywords":"Tunicamycin; Cell culture; SH-SY5Y; Neurotoxicity; Toxicant; Biology; Toxicology; Cell biology; Cell growth; Viability assay; Toxicity; Biochemistry; Apoptosis; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002972072,0.000448925,0.0005151854,0.0003467932,0.0004150176,0.0006616539,0.0002709964,0.0005199656,0.001048759],"category_scores_gemma":[0.0002100999,0.0002386077,0.000453854,0.0002994467,0.0003310639,0.0004269331,0.0004203399,0.001026305,0.0005954034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781533,"about_ca_system_score_gemma":0.0002182013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002304086,"about_ca_topic_score_gemma":0.005399738,"domain_scores_codex":[0.9996592,0.00003045434,0.00005394484,0.00006508243,0.0001361398,0.00005523664],"domain_scores_gemma":[0.9997597,0.00005685571,0.00006296943,0.00003543872,0.0000491353,0.00003598246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003700816,0.00001768472,0.0003263771,0.0000361587,0.000006098162,0.00008590897,0.00005870826,0.00006059775,0.998669,0.00007830094,0.00007711096,0.0005471299],"study_design_scores_gemma":[0.00000954885,0.0001470308,0.01856792,0.00001660129,0.00002841572,0.0004734463,0.0001490693,0.00108588,0.9758368,0.00008093704,0.003584928,0.00001941409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828444,0.00305713,0.007797682,0.000279562,0.00009610842,0.00005419681,0.002235576,0.0001660617,0.0034694],"genre_scores_gemma":[0.9590673,0.004267029,0.01962752,0.000322111,0.00003987682,0.0003799506,0.005221805,0.000112161,0.01096215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304086,"threshold_uncertainty_score":0.004581332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007775886752062883,"score_gpt":0.2263593815030078,"score_spread":0.2185834947509449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}