{"id":"W2990332431","doi":"10.1126/scisignal.aav7934","title":"PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing","year":2019,"lang":"en","type":"article","venue":"Science Signaling","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Cytosol; Intracellular; Cell biology; DNA; Protein kinase R; DNA damage; Chemistry; Biology; Kinase; Biochemistry; Enzyme; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001520009,0.0002766238,0.000238736,0.000163138,0.0001458241,0.0002752749,0.000128511,0.000287007,0.001978589],"category_scores_gemma":[0.0001986506,0.0001281439,0.0002378973,0.00009222569,0.0003106223,0.0002165102,0.0002467609,0.0005072827,0.0007840654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004082931,"about_ca_system_score_gemma":0.0001932445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003405329,"about_ca_topic_score_gemma":0.0003005221,"domain_scores_codex":[0.9998139,0.00003821551,0.00001407634,0.00004639909,0.00004159124,0.00004586701],"domain_scores_gemma":[0.9998272,0.00003364915,0.00004245506,0.00003715731,0.00001543195,0.00004426642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006692702,0.000005566488,0.00007492575,0.00001419988,0.000001331371,0.0000470907,0.000006201426,0.00001067873,0.9993871,0.00007710345,0.00001779497,0.0002910778],"study_design_scores_gemma":[0.00001275193,0.0000695666,0.003219353,0.000003262921,0.000003659976,0.0003535137,0.00001520364,0.0002800913,0.9950542,0.00007535334,0.0009107166,0.000002163309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897899,0.002108096,0.005109416,0.0002165163,0.00005097285,0.00003210112,0.0004900252,0.0002671912,0.001935825],"genre_scores_gemma":[0.996776,0.0002135328,0.001403667,0.00002894389,0.00000730416,0.00001748835,0.0003277769,0.00002269335,0.001202606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978589,"threshold_uncertainty_score":0.006618977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482325989036924,"score_gpt":0.2537211828612827,"score_spread":0.2388979229709135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}