{"id":"W2990341858","doi":"10.1101/847210","title":"Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogramming","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Ottawa Fertility Centre","funders":"","keywords":"Reprogramming; Totipotent; Epigenetics; Biology; Somatic cell; Cell biology; Somatic cell nuclear transfer; Chromatin; Embryo; Histone; Genetics; Embryonic stem cell; Embryogenesis; Blastocyst; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553185,0.0002346427,0.0001703951,0.00008467754,0.0001018922,0.0001799178,0.0001920599,0.0002212843,0.00097008],"category_scores_gemma":[0.0001037403,0.0001133339,0.0001522447,0.00008628957,0.00017596,0.0000956297,0.0001552698,0.0002799669,0.0001855091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194768,"about_ca_system_score_gemma":0.000125172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050884,"about_ca_topic_score_gemma":0.001253255,"domain_scores_codex":[0.9998584,0.0000238363,0.00001283458,0.00003790179,0.00003189384,0.00003501407],"domain_scores_gemma":[0.9999439,0.00000939865,0.00002117364,0.00001030427,0.000005449189,0.000009788067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003843967,0.000003495423,0.00006545278,0.0000179128,0.000001717204,0.000008787368,0.000004389929,0.00002583549,0.9994351,0.00001729435,0.000006969768,0.0003745692],"study_design_scores_gemma":[0.000003668184,0.00006751614,0.001332705,0.000001929074,0.000004488339,0.00004229943,0.000006540349,0.0003094175,0.9974969,0.00000804795,0.0007248591,0.000001580702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927226,0.002200689,0.00323304,0.00006722786,0.00003078729,0.00001849893,0.0002509288,0.00005896276,0.001417225],"genre_scores_gemma":[0.996093,0.000578058,0.001238094,0.00003367391,0.000003892942,0.00001516335,0.0002271151,0.00001312266,0.001797866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050884,"threshold_uncertainty_score":0.003245175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178218964564886,"score_gpt":0.2240350640766295,"score_spread":0.2122528744309807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}