{"id":"W2990350464","doi":"10.3390/pr7120871","title":"Application of an In Vitro Psoriatic Skin Model to Study Cutaneous Metabolization of Tazarotene","year":2019,"lang":"en","type":"article","venue":"Processes","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Centre Hospitalier Universitaire de Québec; Canadian Institutes of Health Research; Université Laval","keywords":"Psoriasis; Tazarotene; Skin equivalent; Dermatology; Dermis; In vivo; Medicine; Keratinocyte; Metabolite; Human skin; In vitro; Epidermis (zoology); Absorption (acoustics); Pharmacology; Pathology; Chemistry; Biology; Biochemistry; Internal medicine; Materials science; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092036,0.0003199116,0.0002172575,0.0001957372,0.0001395135,0.0002318227,0.0001369674,0.0002611537,0.0007069679],"category_scores_gemma":[0.0001009006,0.0001149345,0.0002372242,0.0001406514,0.0001333953,0.0001818147,0.0001354771,0.0006143217,0.000273403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001019615,"about_ca_system_score_gemma":0.0001259675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003801865,"about_ca_topic_score_gemma":0.0005892992,"domain_scores_codex":[0.9998327,0.00005131547,0.00001256846,0.000029796,0.00005071188,0.00002297609],"domain_scores_gemma":[0.9999024,0.00002253541,0.00001882746,0.00002248067,0.00001692979,0.00001690532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002710659,0.00003800432,0.00004176383,0.00001569047,0.000001521274,0.00001983794,0.000006040971,0.00002945051,0.9994938,0.00001531111,0.000006539725,0.0003048073],"study_design_scores_gemma":[0.000005652034,0.0007031033,0.00152978,0.000004027214,0.00001774005,0.0001762825,0.00002344306,0.0008923611,0.9958822,0.00002548358,0.0007365065,0.000003544314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779676,0.001817265,0.01750201,0.00008433645,0.00007083362,0.0001301044,0.0002927165,0.0001006042,0.002034467],"genre_scores_gemma":[0.9832833,0.00143524,0.01289345,0.00007813516,0.00001620797,0.00007617363,0.0002657317,0.00001705171,0.001934725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007069679,"threshold_uncertainty_score":0.002365053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132210361429889,"score_gpt":0.2512437198522796,"score_spread":0.2399216162379807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}