{"id":"W2990350464","doi":"10.3390/pr7120871","title":"Application of an In Vitro Psoriatic Skin Model to Study Cutaneous Metabolization of Tazarotene","year":2019,"lang":"en","type":"article","venue":"Processes","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Centre Hospitalier Universitaire de Québec; Canadian Institutes of Health Research; Université Laval","keywords":"Psoriasis; Tazarotene; Skin equivalent; Dermatology; Dermis; In vivo; Medicine; Keratinocyte; Metabolite; Human skin; In vitro; Epidermis (zoology); Absorption (acoustics); Pharmacology; Pathology; Chemistry; Biology; Biochemistry; Internal medicine; Materials science; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009064039,0.0000927637,0.0002547634,0.0001257679,0.00001716767,0.000002234203,0.0001289359,0.00006745708,0.00001849929],"category_scores_gemma":[0.00004268399,0.00008120228,0.00001874943,0.0003245742,0.00001194119,0.00006952743,0.00002165334,0.00002848111,0.00003283784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001000855,"about_ca_system_score_gemma":0.00004869927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009229711,"about_ca_topic_score_gemma":0.00005452091,"domain_scores_codex":[0.9993706,0.00005682742,0.0002385535,0.0001932693,0.00003458652,0.000106105],"domain_scores_gemma":[0.9995231,0.0000395137,0.0001199436,0.0001928239,0.0001150871,0.00000951396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007152826,0.001573887,0.01114965,0.0002681135,0.0001169543,5.709197e-7,0.003302995,0.003984599,0.9041457,0.00004347887,0.000001530679,0.07469724],"study_design_scores_gemma":[0.001172937,0.0003040842,0.003500375,0.00001068719,0.0001085495,0.000004136397,0.0004150764,0.0007212092,0.9933143,0.0003128038,0.00003726512,0.0000985985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963143,0.001103043,0.001717582,0.000008982494,0.00005224587,0.0007000371,0.00002592135,0.0000162279,0.0000616978],"genre_scores_gemma":[0.9989675,0.00004563875,0.0007056349,0.00001027841,0.000006174502,0.0001072186,0.00007513883,0.000009532955,0.00007288042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08916859,"threshold_uncertainty_score":0.3311333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132210361429889,"score_gpt":0.2512437198522796,"score_spread":0.2399216162379807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}