{"id":"W2990366132","doi":"10.3389/fchem.2019.00791","title":"Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion","year":2019,"lang":"en","type":"article","venue":"Frontiers in Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada","keywords":"Glycoconjugate; Neuraminidase; Adhesion; Glycolipid; Cell adhesion; In vitro; Cell biology; Sialic acid; Chemistry; Receptor; Enzyme; Glycoprotein; Membrane; Cell adhesion molecule; Biophysics; Biochemistry; Cell; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156572,0.0001152072,0.0001653951,0.00003705126,0.00001697165,0.000008232479,0.0002041573,0.0001945626,0.000268784],"category_scores_gemma":[0.00009947838,0.0001173848,0.00007531109,0.0001479541,0.00007552707,0.000004157449,0.00009001583,0.0001300687,0.00001319114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002335392,"about_ca_system_score_gemma":0.00008422154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001230183,"about_ca_topic_score_gemma":0.000001164156,"domain_scores_codex":[0.9990651,0.00002439295,0.0002025413,0.000312321,0.0001950899,0.0002005263],"domain_scores_gemma":[0.9993666,0.000007574287,0.00007806216,0.000405983,0.00007604519,0.0000657109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001744854,0.00005517402,0.03956581,0.0001133613,0.00002229164,0.000002112718,0.00005064032,0.00001712864,0.9446711,0.000003574706,0.01372217,0.001602159],"study_design_scores_gemma":[0.0007940607,0.00006743841,0.003760285,0.00003255634,0.000002908791,0.000002637706,0.0002074678,0.0004424682,0.9829777,0.0001298903,0.01145657,0.0001260539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908333,0.0003411303,0.0001794873,0.0000976491,0.0001160189,0.0002039764,0.0000245058,0.000005766488,0.00819813],"genre_scores_gemma":[0.9900518,0.00005638188,0.001773799,0.00007540653,0.0000531,0.00001452993,0.00005277874,0.00001606428,0.007906158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03830658,"threshold_uncertainty_score":0.4786811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005830640734282194,"score_gpt":0.2403136139396522,"score_spread":0.23448297320537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}