{"id":"W2990421358","doi":"10.1039/c9sc02911g","title":"Optical control of the nuclear bile acid receptor FXR with a photohormone","year":2019,"lang":"en","type":"article","venue":"Chemical Science","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Danmarks Grundforskningsfond; National Research Foundation; European Commission; York University; Aarhus Universitet; New York University","keywords":"Nuclear receptor; Bile acid; Farnesoid X receptor; Chemistry; Control (management); Internal medicine; Medicine; Biochemistry; Computer science; Artificial intelligence; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182932,0.00020375,0.00009126386,0.00008057689,0.0001469069,0.0002102891,0.0002971522,0.0002517195,0.001230208],"category_scores_gemma":[0.0001297858,0.0000949798,0.0001439968,0.00007385434,0.0002758869,0.0002023354,0.0001909062,0.000437051,0.000189063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854208,"about_ca_system_score_gemma":0.000144446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004694888,"about_ca_topic_score_gemma":0.0007584795,"domain_scores_codex":[0.9999346,0.000007600779,0.000002237849,0.00002015704,0.00001917759,0.00001628346],"domain_scores_gemma":[0.9999295,0.00002491957,0.00002122026,0.000008441439,0.000006226333,0.000009632651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004675455,0.00001457274,0.00004223458,0.000041064,0.000003055923,0.000061299,0.00002080447,0.00009744875,0.996552,0.0009051392,0.0001262752,0.00208917],"study_design_scores_gemma":[0.00001106633,0.0001103264,0.0002595257,0.000002301045,0.000003896461,0.00007834893,0.00001303244,0.0009029924,0.9955789,0.00009080699,0.002943798,0.00000488313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604424,0.003010841,0.02649847,0.000714783,0.0002065457,0.00007500347,0.0001550562,0.0002851885,0.008611635],"genre_scores_gemma":[0.9876392,0.001165117,0.006244795,0.0001320741,0.00003769742,0.00005004448,0.00005307911,0.00002983767,0.004648134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230208,"threshold_uncertainty_score":0.004115462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003204221835131303,"score_gpt":0.1825683742762741,"score_spread":0.1793641524411428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}