{"id":"W2990505290","doi":"10.1101/858159","title":"Sequencing Chemically Induced Mutations in the Mutamouse Lacz Reporter Gene Identifies Human Cancer Mutational Signatures","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada; Health Canada","funders":"","keywords":"Mutagenesis; Mutation; Biology; Gene; Genetics; Carcinogenesis; Reporter gene; lac operon; Germline mutation; Molecular biology; Cancer research; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827686,0.0002196386,0.0001690982,0.0006582889,0.0001297791,0.0002494063,0.0001358817,0.0002517605,0.001557031],"category_scores_gemma":[0.0002326917,0.000117247,0.0002186344,0.000280952,0.0001951658,0.0000829767,0.0002127516,0.0002867865,0.0003434233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000216957,"about_ca_system_score_gemma":0.0001653584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000765922,"about_ca_topic_score_gemma":0.001279124,"domain_scores_codex":[0.9998449,0.00001909562,0.00001127838,0.00004248922,0.00006010553,0.0000221037],"domain_scores_gemma":[0.9998766,0.00003284469,0.00003369915,0.00002023796,0.00002049537,0.00001600779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005623705,0.00001629044,0.001944025,0.00001667265,0.000007507918,0.0000359775,0.00001273648,0.00009506448,0.9956994,0.00009409549,0.00004425435,0.001977757],"study_design_scores_gemma":[0.000006933358,0.00014694,0.0213419,0.000002928811,0.00001542908,0.0003977703,0.00002559208,0.0008943207,0.9753116,0.00009640369,0.001756381,0.000003807008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829785,0.0006823036,0.01278607,0.00009193709,0.0000158496,0.00004188417,0.002070604,0.0001665183,0.00116633],"genre_scores_gemma":[0.9814389,0.0005776603,0.01118641,0.00007695016,0.000008791165,0.00004266248,0.003716187,0.00006256839,0.002889845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557031,"threshold_uncertainty_score":0.005208731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01804600967851471,"score_gpt":0.2576940038346949,"score_spread":0.2396479941561802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}