{"id":"W2990538322","doi":"10.1016/j.bpj.2019.11.014","title":"Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; National Institute of General Medical Sciences; Comisión Nacional de Investigación Científica y Tecnológica; Deutsche Forschungsgemeinschaft; National Institutes of Health; International Union of Biochemistry and Molecular Biology; American Society for Biochemistry and Molecular Biology; Pontificia Universidad Católica de Chile; Nvidia","keywords":"Biophysics; RNA polymerase; Operon; Förster resonance energy transfer; Protein structure; Biology; Chemistry; RNA; Crystallography; Escherichia coli; Biochemistry; Physics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009833885,0.0001903873,0.0002724529,0.00001962782,0.00007148565,0.0000453957,0.0004987638,0.0002545606,0.0005319981],"category_scores_gemma":[0.00003242349,0.0001192951,0.00025516,0.00007916232,0.0002667964,0.00000556714,0.0002546824,0.0002893768,0.00002624619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001885837,"about_ca_system_score_gemma":0.00008636379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001381282,"about_ca_topic_score_gemma":0.000008311383,"domain_scores_codex":[0.9987434,0.000103093,0.000332199,0.0002882366,0.0002411761,0.0002919199],"domain_scores_gemma":[0.9991263,0.00001939959,0.0002161262,0.000438028,0.0001063778,0.00009376062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002834965,0.0001423317,0.0005827402,0.00001044672,0.00008421439,0.000001068194,0.00001495976,0.000001787985,0.9961132,0.0001373213,0.00006300307,0.002565424],"study_design_scores_gemma":[0.0005671288,0.0007204961,0.01397172,0.000008083441,0.00003340498,0.00002357883,0.00003609774,0.00006069747,0.9800668,0.00006315448,0.004288889,0.0001599472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997139,0.00003361905,0.001319652,0.0002489846,0.0009642923,0.0001540967,0.00009328578,0.000006052603,0.00004106075],"genre_scores_gemma":[0.9988545,0.0000930863,0.00007440769,0.00004717052,0.0008475561,0.000002717188,0.0000177007,0.00001633543,0.00004648989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01604641,"threshold_uncertainty_score":0.5825006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045167610142174,"score_gpt":0.2177601676737322,"score_spread":0.2073084915723105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}