{"id":"W2990551040","doi":"10.1016/j.jalz.2019.08.196","title":"Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of British Columbia; University of Toronto","funders":"Janssen Biotech; Janssen Research and Development; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Janssen Pharmaceuticals; Alzheimer Society of B.C.; Canadian Institutes of Health Research; Parkinsonfonden; University of California, San Francisco; Health Resources and Services Administration; Eisai; TauRx Pharmaceuticals; FORUM Pharmaceuticals; Avid Radiopharmaceuticals; Parkinson Study Group; AbbVie; Little Family Foundation; New York State Department of Health; Wyeth; University of Southern California; Roche; Centers for Disease Control and Prevention; Novartis; Biogen; National Parkinson Foundation; Pfizer; Mayo Clinic; Merck; Alzheimer's Drug Discovery Foundation; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; AstraZeneca; Tau Consortium; Bristol-Myers Squibb; Genentech; Larry L. Hillblom Foundation; Alzheimer's Association; Huntington's Disease Society of America; National Institutes of Health; Association for Frontotemporal Degeneration; Michael J. Fox Foundation for Parkinson's Research","keywords":"Frontotemporal lobar degeneration; C9orf72; Frontotemporal dementia; Dementia; Psychology; Atrophy; Asymptomatic; Medicine; Pathology; Audiology; Neuroscience; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005620511,0.0003394268,0.0001833068,0.001106813,0.0003190308,0.0003186615,0.0002556296,0.0003806627,0.001187807],"category_scores_gemma":[0.001755012,0.0001431928,0.0001522758,0.0003750213,0.0004326758,0.0002964629,0.0002473465,0.0002021325,0.0001821706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003411965,"about_ca_system_score_gemma":0.0001855887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00272877,"about_ca_topic_score_gemma":0.003557065,"domain_scores_codex":[0.9998666,0.00003007995,0.00001920719,0.00002604296,0.00003313102,0.00002488309],"domain_scores_gemma":[0.999069,0.0001333666,0.0005032349,0.00003292726,0.0001254581,0.0001361539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004158582,0.00006255971,0.9904416,0.00002245632,0.00003524983,0.00114064,0.0002595712,0.0001211102,0.002683953,0.00002176421,0.000160215,0.004635049],"study_design_scores_gemma":[0.000006458303,0.0001155374,0.9973456,0.000004774236,0.000009025577,0.002139144,0.00006462126,0.00006231605,0.0001694884,0.00002957409,0.00005100023,0.00000236301],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992773,0.0001688197,0.00003719422,0.00001724288,0.000001673753,0.000004701586,0.00006756413,0.000005530252,0.0004200084],"genre_scores_gemma":[0.9996052,0.00004961673,0.0001035878,0.00001222567,0.000004805985,0.000004648185,0.0001076734,9.00517e-7,0.0001112908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00272877,"threshold_uncertainty_score":0.005425751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04748013611987598,"score_gpt":0.3062567234374539,"score_spread":0.2587765873175779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}