{"id":"W2990594508","doi":"10.1371/journal.pbio.3000495","title":"Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation","year":2019,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire de Gériatrie de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Weston Brain Institute; Canada First Research Excellence Fund; Alzheimer's Association; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroscience; Biology; Connectome; Neurodegeneration; Atrophy; Substantia nigra; Disease; Functional connectivity; Dopaminergic; Genetics; Pathology; Medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007989909,0.0001452701,0.0002817236,0.00002372432,0.0000495905,0.000006677583,0.00003047567,0.00006751115,0.0001266812],"category_scores_gemma":[0.0001690519,0.0001061758,0.0000496063,0.00007205615,0.0001269714,0.00005439221,0.00004837615,0.00007862774,0.00007840344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001101674,"about_ca_system_score_gemma":0.0001025519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001504393,"about_ca_topic_score_gemma":0.000006666723,"domain_scores_codex":[0.9989754,0.0001650084,0.0001270877,0.0004703098,0.00007801402,0.0001842055],"domain_scores_gemma":[0.9993606,0.00005217822,0.00004974301,0.0002166849,0.00009004475,0.0002308045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001649119,0.001230763,0.9309803,0.0002341409,0.0003471466,0.00009196126,0.00005769389,0.000007237481,0.03340334,0.01166641,0.00004426312,0.02028767],"study_design_scores_gemma":[0.003772866,0.001691302,0.9411423,0.00005986105,0.0003705907,0.00003644524,0.00005588723,0.02209641,0.01818787,0.01180406,0.0005243747,0.0002580486],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971404,0.0005246557,0.0004653723,0.0007123958,0.0001332561,0.0006360984,0.0001145246,0.00005506948,0.0002182331],"genre_scores_gemma":[0.999056,0.00002724565,0.0001355304,0.0005473695,0.00004652248,0.00004875654,0.00008956676,0.000007639423,0.0000413581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02208917,"threshold_uncertainty_score":0.4329724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180459265728187,"score_gpt":0.2767061057825589,"score_spread":0.2549015131252771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}