{"id":"W2990594508","doi":"10.1371/journal.pbio.3000495","title":"Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation","year":2019,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire de Gériatrie de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Weston Brain Institute; Canada First Research Excellence Fund; Alzheimer's Association; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroscience; Biology; Connectome; Neurodegeneration; Atrophy; Substantia nigra; Disease; Functional connectivity; Dopaminergic; Genetics; Pathology; Medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002936935,0.0004002761,0.000384465,0.0005957931,0.0002701552,0.0008689769,0.0002683313,0.0006282506,0.0008350788],"category_scores_gemma":[0.00137877,0.0003478086,0.0003719977,0.0002086958,0.0006399293,0.0008980253,0.0005367374,0.0003868037,0.0001422576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006285246,"about_ca_system_score_gemma":0.000374754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005217017,"about_ca_topic_score_gemma":0.006093434,"domain_scores_codex":[0.9998913,0.00003534064,0.00000422721,0.00002833397,0.00001633505,0.0000245445],"domain_scores_gemma":[0.9996721,0.0001362912,0.00008335693,0.00002013962,0.00003289106,0.00005529206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001380245,0.00005488162,0.02647926,0.00005470276,0.0001217588,0.000599163,0.000273661,0.9168323,0.02441669,0.02050916,0.0005523571,0.009968077],"study_design_scores_gemma":[0.00001700354,0.00006113138,0.01338277,0.00001392764,0.00004360239,0.0002312321,0.0001057568,0.9643421,0.001014433,0.02020813,0.0005591015,0.00002094836],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9347345,0.0003558343,0.06033749,0.0006180117,0.00001487871,0.00002257269,0.0001274439,0.0001204037,0.003668753],"genre_scores_gemma":[0.9973121,0.0001644959,0.001791193,0.00001999806,0.000004752771,0.000008775444,0.00002394455,0.000009862923,0.000664769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005217017,"threshold_uncertainty_score":0.01037329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180459265728187,"score_gpt":0.2767061057825589,"score_spread":0.2549015131252771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}