{"id":"W2990595177","doi":"10.1182/blood-2019-132435","title":"A Randomized Phase 3 Trial of Blinatumomab Vs. Chemotherapy As Post-Reinduction Therapy in High and Intermediate Risk (HR/IR) First Relapse of B-Acute Lymphoblastic Leukemia (B-ALL) in Children and Adolescents/Young Adults (AYAs) Demonstrates Superior Efficacy and Tolerability of Blinatumomab: A Report from Children's Oncology Group Study AALL1331","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Blinatumomab; Medicine; Internal medicine; Mitoxantrone; Oncology; Chemotherapy; Population; Minimal residual disease; Acute lymphocytic leukemia; Hematopoietic stem cell transplantation; Surgery; Transplantation; Leukemia; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002320784,0.001633634,0.00255054,0.0004683424,0.0004521451,0.001335465,0.001159646,0.001776162,0.006419742],"category_scores_gemma":[0.001746056,0.000582667,0.002304475,0.0004400979,0.001311091,0.001150966,0.0005380418,0.004902022,0.001126135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001034947,"about_ca_system_score_gemma":0.001328966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009031257,"about_ca_topic_score_gemma":0.00239147,"domain_scores_codex":[0.9991661,0.0004802986,0.0000390141,0.0001210058,0.00005777371,0.0001357341],"domain_scores_gemma":[0.998597,0.0004852787,0.0002959495,0.0001235434,0.00006637418,0.0004318818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9780905,0.01063307,0.0003343906,0.0002004358,0.0004244992,0.00002161214,0.00003633677,0.0002271289,0.001600602,0.00009832697,0.0004104844,0.007922563],"study_design_scores_gemma":[0.864793,0.1323813,0.001113262,0.00002314936,0.0003139119,0.0000278691,0.00002181037,0.0003563073,0.0003184145,0.0001632444,0.0004770853,0.0000107044],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883246,0.002800513,0.0005247272,0.0007496155,0.0007049061,0.004286223,0.0008249133,0.00009533764,0.001689135],"genre_scores_gemma":[0.9815696,0.002269946,0.001870462,0.001545285,0.0006060747,0.006871277,0.001284907,0.00004467093,0.003937704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006419742,"threshold_uncertainty_score":0.02147621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00622691995846594,"score_gpt":0.2743369109272055,"score_spread":0.2681099909687396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}