{"id":"W2990595177","doi":"10.1182/blood-2019-132435","title":"A Randomized Phase 3 Trial of Blinatumomab Vs. Chemotherapy As Post-Reinduction Therapy in High and Intermediate Risk (HR/IR) First Relapse of B-Acute Lymphoblastic Leukemia (B-ALL) in Children and Adolescents/Young Adults (AYAs) Demonstrates Superior Efficacy and Tolerability of Blinatumomab: A Report from Children's Oncology Group Study AALL1331","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Blinatumomab; Medicine; Internal medicine; Mitoxantrone; Oncology; Chemotherapy; Population; Minimal residual disease; Acute lymphocytic leukemia; Hematopoietic stem cell transplantation; Surgery; Transplantation; Leukemia; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001867911,0.0005270074,0.002751127,0.0006565263,0.00004578559,0.00002540037,0.0002386685,0.0004489455,0.00003039805],"category_scores_gemma":[0.00148781,0.0004337455,0.0001829027,0.0004988844,0.00085341,0.0002182386,0.0001899785,0.0006608288,9.78693e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565461,"about_ca_system_score_gemma":0.0008826825,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01044373,"about_ca_topic_score_gemma":0.0003635535,"domain_scores_codex":[0.9948564,0.000819459,0.002087786,0.001101636,0.0006522248,0.0004825606],"domain_scores_gemma":[0.9965221,0.001210244,0.00106234,0.0007033929,0.0002684535,0.0002334609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5053533,0.009118943,0.4727601,0.0001037365,0.001137677,0.0001607129,0.002072495,0.000001879015,0.006439996,0.000001803795,0.000001499098,0.002847765],"study_design_scores_gemma":[0.4979079,0.01063637,0.4868101,0.0004438525,0.0005475492,0.0004527676,0.0001723824,0.0002576761,0.002571738,0.00002683397,1.444691e-7,0.0001726857],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990432,0.0005821663,0.000005132495,0.00008842146,0.0001505591,0.008553332,0.0001510826,0.00003125106,0.000006115234],"genre_scores_gemma":[0.9967495,0.002532572,0.000225193,0.00002584671,0.00009631311,0.0001392081,0.000161981,0.00006431832,0.000005130576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01404998,"threshold_uncertainty_score":0.9998114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00622691995846594,"score_gpt":0.2743369109272055,"score_spread":0.2681099909687396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}